Compare
Two to six compounds, domain by domain. A higher number in one column is not added to another column. Unscored analogues are left blank rather than copied from a parent chemical.
BPA, BPAF, BPSDEHP, DINP, DINCHOlanzapine, risperidone, aripiprazoleFluoxetine, sertraline, methylphenidatePFOS, PFOAParaquat, rotenone, boscalidMelatonin, paraquat, rotenone
| Domain | Fluoxetine | Sertraline | Methylphenidate |
|---|---|---|---|
| REP Reproductive | +3 H1 · mechanistic, cellular, or high-dose animal · Low | — No headline | +2 H0 · no meaningful human evidence · Very low |
| DEV Developmental | +2 H2 · strong experimental, limited human · Low | — No headline | +2 H3 · substantial human observation plus biology · Moderate |
| NEUROENDO Neuroendocrine / HPA | +3 H4 · established at relevant human exposure · High | — No headline | +3 H4 · established at relevant human exposure · High |
| IMM Immune | — No headline | — No headline | — No headline |
| MET Metabolic | +2 H2 · strong experimental, limited human · Low | — No headline | +2 H1 · mechanistic, cellular, or high-dose animal · Low |
| MITO Mitochondrial | +2 H1 · mechanistic, cellular, or high-dose animal · Low | — No headline | +2 H1 · mechanistic, cellular, or high-dose animal · Low |
| REDOX Redox | +2 H1 · mechanistic, cellular, or high-dose animal · Low | — No headline | +2 H1 · mechanistic, cellular, or high-dose animal · Low |