Compounds
Each column is a domain headline: the strongest independent mechanistic cluster, not a sum. Empty cells are unscored, not evidence of safety. Seed numbers are hypotheses.
116 shown
| Compound | Category | REP | DEV | NEUROENDO | IMM | MET | MITO | REDOX | Human relevance | Confidence | Last reviewed |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2,4-D 2,4-Dichlorophenoxyacetic acid | herbicide Phenoxy herbicide | — | — | — | — | — | — | — | — | — | — |
| Acetamiprid Acetamiprid | insecticide Neonicotinoid | — | — | — | — | — | — | — | — | — | — |
| Amiodarone Amiodarone | pharmaceutical Antiarrhythmic | — | — | — | — | — | — | — | — | — | — |
| Amitriptyline (representative TCA) representative stand in | pharmaceutical Tricyclic antidepressant | — | — | — | — | — | — | — | — | — | — |
| Aripiprazole Aripiprazole | pharmaceutical Atypical antipsychotic | — | — | — | — | — | — | — | — | — | — |
| ATBC Acetyl tributyl citrate | plasticiser Replacement plasticiser | — | — | — | — | — | — | — | — | — | — |
| Atorvastatin Atorvastatin | pharmaceutical Statin | — | — | — | — | — | — | — | — | — | — |
| Atrazine Atrazine | herbicide Triazine herbicide | — | — | — | — | — | — | — | — | — | — |
| BBP Benzyl butyl phthalate | plasticiser Phthalate plasticiser | — | — | — | — | — | — | — | — | — | — |
| BDE-47 (representative PBDE) representative stand in | flame retardant PBDE | — | — | — | — | — | — | — | — | — | — |
| Benzophenone UV filters class placeholder | cosmetic ingredient UV filter class | — | — | — | — | — | — | — | — | — | — |
| Benzyl benzoate Benzyl benzoate | cosmetic ingredient Fragrance ingredient | — | — | — | — | — | — | — | — | — | — |
| Bixafen Bixafen | fungicide SDHI fungicide | — | — | — | — | — | +4 | — | H1 | moderate | 2026-10-01 |
| Boscalid Boscalid | fungicide SDHI fungicide | — | — | — | — | — | +4 | — | H1 | moderate | 2026-10-01 |
| BPA Bisphenol A | bisphenol Bisphenol | +4 | +4 | — | +4 | +4 | +3 | +3 | H1–H3 | low–moderate | 2026-10-01 |
| BPAF Bisphenol AF | bisphenol Bisphenol | — | — | — | — | — | — | — | — | — | — |
| BPAP Bisphenol AP | bisphenol Bisphenol | — | — | — | — | — | — | — | — | — | — |
| BPB Bisphenol B | bisphenol Bisphenol | — | — | — | — | — | — | — | — | — | — |
| BPF Bisphenol F | bisphenol Bisphenol | — | — | — | — | — | — | — | — | — | — |
| BPS Bisphenol S | bisphenol Bisphenol | — | — | — | — | — | — | — | — | — | — |
| BPZ Bisphenol Z | bisphenol Bisphenol | — | — | — | — | — | — | — | — | — | — |
| Carbamazepine Carbamazepine | pharmaceutical Antiseizure medication | — | — | — | — | — | — | — | — | — | — |
| Chlorpyrifos Chlorpyrifos | insecticide Organophosphate insecticide | — | — | — | — | — | — | — | — | — | — |
| Citalopram Citalopram | pharmaceutical SSRI | — | — | — | — | — | — | — | — | — | — |
| Clothianidin Clothianidin | insecticide Neonicotinoid | — | — | — | — | — | — | — | — | — | — |
| Clozapine Clozapine | pharmaceutical Atypical antipsychotic | — | — | — | — | — | — | — | — | — | — |
| Cosmetic preservatives class placeholder | cosmetic ingredient Preservative class | — | — | — | — | — | — | — | — | — | — |
| Cypermethrin Cypermethrin | insecticide Pyrethroid | — | — | — | — | — | — | — | — | — | — |
| DBP Dibutyl phthalate | plasticiser Phthalate plasticiser | — | — | — | — | — | — | — | — | — | — |
| DDE p,p'-DDE | metabolite Organochlorine metabolite | — | — | — | — | — | — | — | — | — | — |
| DDT DDT | insecticide Organochlorine insecticide | — | — | — | — | — | — | — | — | — | — |
| DEHP Bis(2-ethylhexyl) phthalate | plasticiser Phthalate plasticiser | +4 | +4 | — | — | +3 | +3 | +3 | H1–H3 | low–moderate | 2026-10-01 |
| DEHT Bis(2-ethylhexyl) terephthalate | plasticiser Replacement plasticiser | — | — | — | — | — | — | — | — | — | — |
| Deltamethrin Deltamethrin | insecticide Pyrethroid | — | — | — | — | — | — | — | — | — | — |
| DEP Diethyl phthalate | plasticiser Phthalate | — | — | — | — | — | — | — | — | — | — |
| Dexamethasone Dexamethasone | pharmaceutical Glucocorticoid | — | — | — | — | — | — | — | — | — | — |
| Dexamphetamine Dextroamphetamine | pharmaceutical Stimulant | — | — | — | — | — | — | — | — | — | — |
| Diazinon Diazinon | insecticide Organophosphate insecticide | — | — | — | — | — | — | — | — | — | — |
| DIBP Diisobutyl phthalate | plasticiser Phthalate plasticiser | — | — | — | — | — | — | — | — | — | — |
| DIDP Diisodecyl phthalate | plasticiser Phthalate plasticiser | — | — | — | — | — | — | — | — | — | — |
| Difenoconazole Difenoconazole | fungicide Azole fungicide | — | — | — | — | — | — | — | — | — | — |
| DINCH Diisononyl cyclohexane-1,2-dicarboxylate | plasticiser Replacement plasticiser | — | — | — | — | — | — | — | — | — | — |
| DINP Diisononyl phthalate | plasticiser Phthalate plasticiser | — | — | — | — | — | — | — | — | — | — |
| Dioxin-like compounds class placeholder | pollutant Dioxin-like mixture | — | — | — | — | — | — | — | — | — | — |
| Dolutegravir (representative INSTI) representative stand in | pharmaceutical Integrase strand-transfer inhibitor | — | — | — | — | — | — | — | — | — | — |
| Dutasteride Dutasteride | pharmaceutical 5α-reductase inhibitor | — | — | — | — | — | — | — | — | — | — |
| Escitalopram Escitalopram | pharmaceutical SSRI | — | — | — | — | — | — | — | — | — | — |
| Estradiol Estradiol | hormone Endogenous estrogen | — | — | — | — | — | — | — | — | — | — |
| Ethinylestradiol Ethinylestradiol | pharmaceutical Synthetic estrogen | — | — | — | — | — | — | — | — | — | — |
| ETU Ethylenethiourea | metabolite Dithiocarbamate metabolite | — | — | — | — | — | — | — | — | — | — |
| Finasteride Finasteride | pharmaceutical 5α-reductase inhibitor | — | — | — | — | — | — | — | — | — | — |
| Fluopyram Fluopyram | fungicide SDHI fungicide | — | — | — | — | — | +4 | — | H1 | moderate | 2026-10-01 |
| Fluoxetine Fluoxetine | pharmaceutical SSRI | +3 | +2 | +3 | — | +2 | +2 | +2 | H1–H4 | low–high | 2026-10-01 |
| Fluvoxamine Fluvoxamine | pharmaceutical SSRI | — | — | — | — | — | — | — | — | — | — |
| Fluxapyroxad Fluxapyroxad | fungicide SDHI fungicide | — | — | — | — | — | +4 | — | H1 | moderate | 2026-10-01 |
| Fragrance chemicals class placeholder | cosmetic ingredient Fragrance class | — | — | — | — | — | — | — | — | — | — |
| Glyphosate Glyphosate | herbicide Herbicide active ingredient | — | — | — | — | — | — | — | — | — | — |
| Glyphosate-based herbicide formulation | herbicide Herbicide formulation | — | — | — | — | — | — | — | — | — | — |
| Haloperidol Haloperidol | pharmaceutical Typical antipsychotic | — | — | — | — | — | — | — | — | — | — |
| HFPO-DA (representative replacement PFAS) representative stand in | pfas Replacement PFAS | — | — | — | — | — | — | — | — | — | — |
| Ibuprofen Ibuprofen | pharmaceutical NSAID | — | — | — | — | — | — | — | — | — | — |
| Imidacloprid Imidacloprid | insecticide Neonicotinoid | — | — | — | — | — | — | — | — | — | — |
| Levonorgestrel (representative progestin) representative stand in | pharmaceutical Progestin | — | — | — | — | — | — | — | — | — | — |
| Lisdexamfetamine Lisdexamfetamine | pharmaceutical Stimulant | — | — | — | — | — | — | — | — | — | — |
| Lithium Lithium | pharmaceutical Mood stabiliser | — | — | — | — | — | — | — | — | — | — |
| Malathion Malathion | insecticide Organophosphate insecticide | — | — | — | — | — | — | — | — | — | — |
| Mancozeb Mancozeb | fungicide Dithiocarbamate fungicide | — | — | — | — | — | — | — | — | — | — |
| Melatonin Melatonin | hormone Endogenous hormone / pharmaceutical | +1 | +1 | Phys. | -2 | — | -3 | -4 | H0–H1 | very low–low | 2026-10-01 |
| Methylphenidate Methylphenidate | pharmaceutical Stimulant | +2 | +2 | +3 | — | +2 | +2 | +2 | H0–H4 | very low–high | 2026-10-01 |
| Micro- and nanoplastics class placeholder | pollutant Particle mixture | — | — | — | — | — | — | — | — | — | — |
| Mirtazapine Mirtazapine | pharmaceutical Antidepressant | — | — | — | — | — | — | — | — | — | — |
| Morphine (representative chronic opioid) representative stand in | pharmaceutical Opioid | — | — | — | — | — | — | — | — | — | — |
| Olanzapine Olanzapine | pharmaceutical Atypical antipsychotic | +2 | +2 | +3 | — | +4 | +3 | +3 | H1–H4 | low–high | 2026-10-01 |
| Paliperidone Paliperidone | pharmaceutical Atypical antipsychotic | — | — | — | — | — | — | — | — | — | — |
| Parabens class placeholder | cosmetic ingredient Preservative class | — | — | — | — | — | — | — | — | — | — |
| Paracetamol Paracetamol | pharmaceutical Analgesic | — | — | — | — | — | — | — | — | — | — |
| Paraquat Paraquat | herbicide Bipyridyl herbicide | — | — | — | +3 | — | +4 | +4 | H1–H2 | low–high | 2026-10-01 |
| Paroxetine Paroxetine | pharmaceutical SSRI | — | — | — | — | — | — | — | — | — | — |
| PCBs class placeholder | pollutant Organochlorine mixture | — | — | — | — | — | — | — | — | — | — |
| Permethrin Permethrin | insecticide Pyrethroid | — | — | — | — | — | — | — | — | — | — |
| PFHxA (representative short-chain PFAS) representative stand in | pfas Short-chain PFAS | — | — | — | — | — | — | — | — | — | — |
| PFHxS Perfluorohexane sulfonic acid | pfas PFAS | — | — | — | — | — | — | — | — | — | — |
| PFNA Perfluorononanoic acid | pfas Long-chain PFAS | — | — | — | — | — | — | — | — | — | — |
| PFOA Perfluorooctanoic acid | pfas Long-chain PFAS | — | — | — | — | — | — | — | — | — | — |
| PFOS Perfluorooctane sulfonic acid | pfas Long-chain PFAS | +3 | +4 | — | +4 | +4 | +3 | +3 | H1–H3 | low–moderate | 2026-10-01 |
| Phenobarbital Phenobarbital | pharmaceutical Barbiturate | — | — | — | — | — | — | — | — | — | — |
| Phenytoin Phenytoin | pharmaceutical Antiseizure medication | — | — | — | — | — | — | — | — | — | — |
| Pravastatin Pravastatin | pharmaceutical Statin | — | — | — | — | — | — | — | — | — | — |
| Prednisolone Prednisolone | pharmaceutical Glucocorticoid | — | — | — | — | — | — | — | — | — | — |
| Prednisone Prednisone | pharmaceutical Glucocorticoid | — | — | — | — | — | — | — | — | — | — |
| Prochloraz Prochloraz | fungicide Imidazole fungicide | — | — | — | — | — | — | — | — | — | — |
| Procymidone Procymidone | fungicide Dicarboximide fungicide | — | — | — | — | — | — | — | — | — | — |
| Propiconazole Propiconazole | fungicide Azole fungicide | — | — | — | — | — | — | — | — | — | — |
| Pyraclostrobin Pyraclostrobin | fungicide Strobilurin fungicide | — | — | — | — | — | — | — | — | — | — |
| Quetiapine Quetiapine | pharmaceutical Atypical antipsychotic | — | — | — | — | — | — | — | — | — | — |
| Risperidone Risperidone | pharmaceutical Atypical antipsychotic | +4 | +3 | +4 | — | +3 | — | — | H2–H4 | low–high | 2026-10-01 |
| Ritonavir (representative protease inhibitor) representative stand in | pharmaceutical HIV protease inhibitor | — | — | — | — | — | — | — | — | — | — |
| Rosuvastatin Rosuvastatin | pharmaceutical Statin | — | — | — | — | — | — | — | — | — | — |
| Rotenone Rotenone | pesticide Complex I inhibitor | — | — | — | — | — | +4 | +4 | H1 | high | 2026-10-01 |
| Sertraline Sertraline | pharmaceutical SSRI | — | — | — | — | — | — | — | — | — | — |
| Simvastatin Simvastatin | pharmaceutical Statin | — | — | — | — | — | — | — | — | — | — |
| Spironolactone Spironolactone | pharmaceutical Mineralocorticoid receptor antagonist | — | — | — | — | — | — | — | — | — | — |
| TBBPA Tetrabromobisphenol A | flame retardant Brominated flame retardant | — | — | — | — | — | — | — | — | — | — |
| TCEP Tris(2-chloroethyl) phosphate | flame retardant Organophosphate ester | — | — | — | — | — | — | — | — | — | — |
| TCIPP Tris(1-chloro-2-propyl) phosphate | flame retardant Organophosphate ester | — | — | — | — | — | — | — | — | — | — |
| TDCIPP Tris(1,3-dichloro-2-propyl) phosphate | flame retardant Organophosphate ester | — | — | — | — | — | — | — | — | — | — |
| Tebuconazole Tebuconazole | fungicide Azole fungicide | — | — | — | — | — | — | — | — | — | — |
| TFA Trifluoroacetic acid | industrial chemical Ultra-short-chain fluorinated acid | — | +3 | +4 | — | — | — | — | H2 | low | 2026-10-01 |
| Thiamethoxam Thiamethoxam | insecticide Neonicotinoid | — | — | — | — | — | — | — | — | — | — |
| TOTM Trioctyl trimellitate | plasticiser Trimellitate plasticiser | — | — | — | — | — | — | — | — | — | — |
| TPHP Triphenyl phosphate | flame retardant Organophosphate ester | — | — | — | — | — | — | — | — | — | — |
| Tributyltin Tributyltin | industrial chemical Organotin | — | — | — | — | — | — | — | — | — | — |
| UV-328 UV-328 | industrial chemical UV stabiliser | — | — | — | — | — | — | — | — | — | — |
| Valproate Valproic acid | pharmaceutical Antiseizure medication | +4 | +4 | — | — | +4 | +3 | +3 | H1–H4 | low–high | 2026-10-01 |
| Vinclozolin Vinclozolin | fungicide Dicarboximide fungicide | — | — | — | — | — | — | — | — | — | — |
| Zidovudine (representative older NRTI) representative stand in | pharmaceutical Nucleoside reverse transcriptase inhibitor | — | — | — | — | — | — | — | — | — | — |