Compare
Two to six compounds, domain by domain. A higher number in one column is not added to another column. Unscored analogues are left blank rather than copied from a parent chemical.
BPA, BPAF, BPSDEHP, DINP, DINCHOlanzapine, risperidone, aripiprazoleFluoxetine, sertraline, methylphenidatePFOS, PFOAParaquat, rotenone, boscalidMelatonin, paraquat, rotenone
| Domain | Melatonin | Paraquat | Rotenone |
|---|---|---|---|
| REP Reproductive | +1 H0 · no meaningful human evidence · Very low | — No headline | — No headline |
| DEV Developmental | +1 H0 · no meaningful human evidence · Very low | — No headline | — No headline |
| NEUROENDO Neuroendocrine / HPA | Phys. No headline | — No headline | — No headline |
| IMM Immune | -2 H1 · mechanistic, cellular, or high-dose animal · Low | +3 H1 · mechanistic, cellular, or high-dose animal · Low | — No headline |
| MET Metabolic | — No headline | — No headline | — No headline |
| MITO Mitochondrial | -3 H1 · mechanistic, cellular, or high-dose animal · Low | +4 H2 · strong experimental, limited human · High | +4 H1 · mechanistic, cellular, or high-dose animal · High |
| REDOX Redox | -4 H1 · mechanistic, cellular, or high-dose animal · Low | +4 H2 · strong experimental, limited human · High | +4 H1 · mechanistic, cellular, or high-dose animal · High |