Rotenone

Category: pesticide · Complex I inhibitor
Record: specific compound · unknown
Identifiers: CAS 83-79-4
Aliases: —

Mitochondrial complex I inhibitor, used historically as a pesticide and piscicide. Complex I disruption is not an estrogen-receptor effect.

Flags: environmental chemical

Phase-1 numbers are seed hypotheses. They are not curated consensus, not a toxicity total, and not a statement of human risk. Association is not written as causation.

REP

Reproductive

—

DEV

Developmental

—

NEUROENDO

Neuroendocrine / HPA

—

IMM

Immune

—

MET

Metabolic

—

MITO

Mitochondrial

REDOX

Redox

Left of the centre line is protective or restorative. Right is disruptive. Physiological activity is labelled and is not drawn as disruption. Domains are not added together.

REP · Reproductive

—

No quantitative mechanistic score is stored for this domain.

Direction: Direction uncertain

Confidence: —

Human relevance: —

Findings 0 supporting / 0 contradictory · 0 capped

DEV · Developmental

—

No quantitative mechanistic score is stored for this domain.

Direction: Direction uncertain

Confidence: —

Human relevance: —

Findings 0 supporting / 0 contradictory · 0 capped

NEUROENDO · Neuroendocrine / HPA

—

No quantitative mechanistic score is stored for this domain.

Direction: Direction uncertain

Confidence: —

Human relevance: —

Findings 0 supporting / 0 contradictory · 0 capped

IMM · Immune

—

No quantitative mechanistic score is stored for this domain.

Direction: Direction uncertain

Confidence: —

Human relevance: —

Findings 0 supporting / 0 contradictory · 0 capped

MET · Metabolic

—

No quantitative mechanistic score is stored for this domain.

Direction: Direction uncertain

Confidence: —

Human relevance: —

Findings 0 supporting / 0 contradictory · 0 capped

MITO · Mitochondrial

Headline +4 is the strongest independent cluster (ETC_COMPLEX_I: ETC complex I). Other clusters and child mechanisms were not added. Human relevance is the relevance of the headline cluster, not the maximum relevance anywhere in the domain, and it is not multiplied into the score. No curated scientific findings are linked yet. The number is a seed assessment, not a literature count. Direction DISRUPTIVE. Confidence HIGH. Human relevance H1. Supporting findings 0. Contradictory findings 0. Curation SEED_HYPOTHESIS.

Direction: Disruptive signal

Confidence: High

Human relevance: H1 · mechanistic, cellular, or high-dose animal

Findings 0 supporting / 0 contradictory · 0 capped

REDOX · Redox

Headline +4 is the strongest independent cluster (ROS_GENERATION: ROS (total)). Other clusters and child mechanisms were not added. Human relevance is the relevance of the headline cluster, not the maximum relevance anywhere in the domain, and it is not multiplied into the score. No curated scientific findings are linked yet. The number is a seed assessment, not a literature count. Direction DISRUPTIVE. Confidence HIGH. Human relevance H1. Supporting findings 0. Contradictory findings 0. Curation SEED_HYPOTHESIS.

Direction: Disruptive signal

Confidence: High

Human relevance: H1 · mechanistic, cellular, or high-dose animal

Findings 0 supporting / 0 contradictory · 0 capped