EDCtox

Mechanistic evidence atlas. Scores summarise biological direction and magnitude. They are not a toxicity rank or a human-risk number.

Compounds

Boscalid

Boscalid

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Category
fungicide · SDHI fungicide
Record
specific compound · unknown
Identifiers
CAS 188425-85-6
Aliases
Nicobifen

SDHI fungicide whose fungicidal mode of action is mitochondrial complex II. Mammalian and human exposure relevance is a separate question from target-site potency.

Flags: environmental chemical

Phase-1 numbers are seed hypotheses. They are not curated consensus, not a toxicity total, and not a statement of human risk. Association is not written as causation.

MITO · Mitochondrial bioenergetics

ETC complex II

ETC_COMPLEX_II · group ETC_COMPLEX_II · Electron transport complexes · scorable

Succinate dehydrogenase / complex II. SDHI fungicides act here in the target organism. Mammalian human relevance is a separate field.

Score +4Disruptive signalModerate confidenceH1seed hypothesisreview v1

Strong mechanistic complex II disruption. This is the fungicidal mode of action. Current human evidence at environmental exposure is weak.

Complex II cluster. Succinate and fumarate would be capped here. Reorganization energy is a different, unscored field.

Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk. Human relevance is H1. Do not read fungal target potency as clinical or environmental human risk.

  • Insufficient human evidence
  • Dose relevance uncertain

No evidence finding is linked yet.

Score history
  • 2026-10-03: — → +4. Initial seed hypothesis, version 1. Not a curated consensus.

Reorganization energy

REORGANIZATION_ENERGY · group REORGANIZATION_ENERGY · Bioenergetic output · research only

Marcus reorganization energy is a research field for electron-transfer theory. It must not be scored from ATP, oxygen consumption, or other indirect bioenergetic changes.

Score not quantifiedDirection uncertainVery low confidenceH0seed hypothesisreview v1

The field is open. No score is assigned, and none is inferred from complex II inhibition.

Research-only policy. Excluded from the mitochondrial headline.

Marcus reorganization energy requires direct evidence. ATP or respiration changes are not that evidence.

    No evidence finding is linked yet.

    Score history
    • 2026-10-03: — → —. Initial seed hypothesis, version 1. Not a curated consensus.