EDCtox

Mechanistic evidence atlas. Scores summarise biological direction and magnitude. They are not a toxicity rank or a human-risk number.

Compounds

BPA

Bisphenol A

Add to comparison
Category
bisphenol · Bisphenol
Record
specific compound · restricted
Identifiers
CAS 80-05-7 · C15H16O2
Aliases
4,4'-(propane-2,2-diyl)diphenol, Bisphenol A

High-production-volume bisphenol used in polycarbonate plastics and epoxy resins. Domain scores are seed hypotheses about biological activity, not a single risk number.

Restrictions differ by use and jurisdiction.

Flags: environmental chemical

Phase-1 numbers are seed hypotheses. They are not curated consensus, not a toxicity total, and not a statement of human risk. Association is not written as causation.

REP · Reproductive endocrinology

ER-alpha agonism

ER_ALPHA_AGONISM · group ESTROGEN_RECEPTOR · Estrogen receptor axis · scorable

Estrogen receptor alpha agonism or activation. A binding or reporter result is not itself a human disease claim.

Score +4Disruptive signalModerate confidenceH3seed hypothesisreview v1

Estrogen-receptor-alpha activity is a substantial disruptive signal in this seed.

Domain headline for reproductive endocrinology. Other estrogen-receptor children are the same cluster and are not scored again.

Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

    Discussed as a mechanism · 2026 · Phase 1 structural seed record (not a publication) · structural seed, not a citation

    Structural example: one source row can point at the BPA estrogen-receptor assessment.

    Not scientific evidence. Present only to prove the source/finding split.

    not applicable · study quality not assessed · dose metric unknown

    Score history
    • 2026-10-03: — → +4. Initial seed hypothesis, version 1. Not a curated consensus.

    DEV · Developmental endocrinology

    Brain sexual differentiation

    BRAIN_SEXUAL_DIFFERENTIATION · group DEVELOPMENTAL_MORPHOLOGY · Developmental differentiation · scorable

    Brain sexual differentiation. Mechanism node for evidence linkage. A row here is not itself a finding.

    Score +4Disruptive signalModerate confidenceH3seed hypothesisreview v1

    Developmental seed hypothesis at the conservative established-concern end of the discussed range.

    Attached to brain sexual differentiation rather than inferred to be only an adult receptor effect.

    Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → +4. Initial seed hypothesis, version 1. Not a curated consensus.

      IMM · Immunology and immunoendocrinology

      Cytokine signalling

      CYTOKINE_SIGNALING · group CYTOKINE_INFLAMMATION · Innate immunity and cytokines · scorable

      Cytokine signalling. Mechanism node for evidence linkage. A row here is not itself a finding.

      Score +4Disruptive signalLow confidenceH2seed hypothesisreview v1

      Immune activation and cytokine signalling are seeded as one inflammatory cluster.

      TNF, IL-6, NF-κB, and immune activation share this cluster and are not additional points.

      Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      • Insufficient human evidence

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → +4. Initial seed hypothesis, version 1. Not a curated consensus.

      MET · Systemic metabolism

      Insulin resistance

      INSULIN_RESISTANCE · group INSULIN_SIGNALING · Insulin signalling pathway · scorable

      Impaired insulin action at target tissues. A mechanistic insulin-signalling change is not automatically a diagnosis of diabetes.

      Score +4Disruptive signalModerate confidenceH3seed hypothesisreview v1

      Pathway: BPA insulin-signalling cluster. Not summed with other domains.

      Metabolic seed hypothesis. This is not a claim that BPA exposure is established to cause diabetes.

      Headline of the insulin-signalling cluster.

      Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

        Discussed as a mechanism · 2026 · Phase 1 structural seed record (not a publication) · structural seed, not a citation

        Structural example: the same source row also points at the BPA insulin-resistance assessment.

        Same publication record, second finding. The source is not duplicated.

        not applicable · study quality not assessed · dose metric unknown

        Score history
        • 2026-10-03: — → +4. Initial seed hypothesis, version 1. Not a curated consensus.

        IRS1

        IRS1 · group INSULIN_SIGNALING · Insulin signalling pathway · scorable

        IRS1. Mechanism node for evidence linkage. A row here is not itself a finding.

        Score +3Disruptive signalLow confidenceH1seed hypothesisreview v1

        Pathway: BPA insulin-signalling cluster. Not summed with other domains.

        Downstream insulin-signalling node. Same cluster as insulin resistance.

        Capped into the insulin-signalling group so it cannot raise the domain total.

        Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

        • Insufficient human evidence

        No evidence finding is linked yet.

        Score history
        • 2026-10-03: — → +3. Initial seed hypothesis, version 1. Not a curated consensus.

        AKT

        AKT · group INSULIN_SIGNALING · Insulin signalling pathway · scorable

        AKT. Mechanism node for evidence linkage. A row here is not itself a finding.

        Score +2Disruptive signalLow confidenceH1seed hypothesisreview v1

        Pathway: BPA insulin-signalling cluster. Not summed with other domains.

        Downstream insulin-signalling node. Same cluster as insulin resistance.

        Capped into the insulin-signalling group.

        Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

        • Insufficient human evidence

        No evidence finding is linked yet.

        Score history
        • 2026-10-03: — → +2. Initial seed hypothesis, version 1. Not a curated consensus.

        MITO · Mitochondrial bioenergetics

        ATP production

        ATP_PRODUCTION · group BIOENERGETIC_OUTPUT · Bioenergetic output · scorable

        ATP production. Mechanism node for evidence linkage. A row here is not itself a finding.

        Score +3Disruptive signalLow confidenceH1seed hypothesisreview v1

        Mitochondrial seed at +3. Not inferred to be a reorganization-energy effect.

        Bioenergetic-output cluster only.

        Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

        • Insufficient human evidence
        • Dose relevance uncertain

        No evidence finding is linked yet.

        Score history
        • 2026-10-03: — → +3. Initial seed hypothesis, version 1. Not a curated consensus.

        REDOX · Redox and cellular stress

        ROS (total)

        ROS_TOTAL · group ROS_GENERATION · Reactive species · scorable

        ROS (total). Mechanism node for evidence linkage. A row here is not itself a finding.

        Score +3Disruptive signalLow confidenceH1seed hypothesisreview v1

        Redox seed at +3.

        ROS generation cluster. Lipid peroxidation is not scored again.

        Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

        • Insufficient human evidence

        No evidence finding is linked yet.

        Score history
        • 2026-10-03: — → +3. Initial seed hypothesis, version 1. Not a curated consensus.