EDCtox

Mechanistic evidence atlas. Scores summarise biological direction and magnitude. They are not a toxicity rank or a human-risk number.

Compounds

Fluoxetine

Fluoxetine

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Category
pharmaceutical · SSRI
Record
specific compound · in current use
Identifiers
CAS 54910-89-3
Aliases
—

SSRI. Serotonergic activity is intended pharmacology. Estrogen-receptor and steroidogenic findings are stored as context-dependent, not as a resolved disease claim.

Flags: pharmaceutical

Phase-1 numbers are seed hypotheses. They are not curated consensus, not a toxicity total, and not a statement of human risk. Association is not written as causation.

REP · Reproductive endocrinology

ER-alpha agonism

ER_ALPHA_AGONISM · group ESTROGEN_RECEPTOR · Estrogen receptor axis · scorable

Estrogen receptor alpha agonism or activation. A binding or reporter result is not itself a human disease claim.

Score +3Context-dependentLow confidenceH1seed hypothesisreview v1

Reproductive seed at +3 with context-dependent estrogen-receptor and steroidogenic expression findings. The literature is not one direction.

Conflicting flag is set. A receptor-expression result is not a human disease claim.

Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

  • Conflicting evidence
  • Insufficient human evidence

No evidence finding is linked yet.

Score history
  • 2026-10-03: — → +3. Initial seed hypothesis, version 1. Not a curated consensus.

DEV · Developmental endocrinology

Neurodevelopment

NEURODEVELOPMENT · group NEURODEVELOPMENT · Developmental differentiation · scorable

Neurodevelopment. Mechanism node for evidence linkage. A row here is not itself a finding.

Score +2Disruptive signalLow confidenceH2seed hypothesisreview v1

Developmental seed at +2, the lower end of +2 to +3.

Not the serotonergic pharmacology score.

Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

  • Developmental relevance uncertain

No evidence finding is linked yet.

Score history
  • 2026-10-03: — → +2. Initial seed hypothesis, version 1. Not a curated consensus.

NEUROENDO · Neuroendocrine, HPA, and circadian

Serotonin

SEROTONIN · group SEROTONIN · HPA axis · scorable

Serotonin. Mechanism node for evidence linkage. A row here is not itself a finding.

Score +3Context-dependentHigh confidenceH4seed hypothesisreview v1

Serotonin-reuptake inhibition is intended pharmacology. The score marks strong biological activity, not an adverse-event rank.

Separate from the context-dependent estrogen-receptor row.

Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

    No evidence finding is linked yet.

    Score history
    • 2026-10-03: — → +3. Initial seed hypothesis, version 1. Not a curated consensus.

    MET · Systemic metabolism

    Insulin resistance

    INSULIN_RESISTANCE · group INSULIN_SIGNALING · Insulin signalling pathway · scorable

    Impaired insulin action at target tissues. A mechanistic insulin-signalling change is not automatically a diagnosis of diabetes.

    Score +2Disruptive signalLow confidenceH2seed hypothesisreview v1

    Metabolic seed at +2.

    Modest relative to olanzapine in this seed.

    Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → +2. Initial seed hypothesis, version 1. Not a curated consensus.

      MITO · Mitochondrial bioenergetics

      ATP production

      ATP_PRODUCTION · group BIOENERGETIC_OUTPUT · Bioenergetic output · scorable

      ATP production. Mechanism node for evidence linkage. A row here is not itself a finding.

      Score +2Disruptive signalLow confidenceH1seed hypothesisreview v1

      Mitochondrial seed at +2.

      Experimental relevance to therapeutic dose is uncertain.

      Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      • Insufficient human evidence
      • Dose relevance uncertain

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → +2. Initial seed hypothesis, version 1. Not a curated consensus.

      REDOX · Redox and cellular stress

      ROS (total)

      ROS_TOTAL · group ROS_GENERATION · Reactive species · scorable

      ROS (total). Mechanism node for evidence linkage. A row here is not itself a finding.

      Score +2Disruptive signalLow confidenceH1seed hypothesisreview v1

      Redox seed at +2, the lower end of +2 to +3.

      ROS cluster only.

      Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      • Insufficient human evidence

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → +2. Initial seed hypothesis, version 1. Not a curated consensus.