EDCtox

Mechanistic evidence atlas. Scores summarise biological direction and magnitude. They are not a toxicity rank or a human-risk number.

Compounds

PFOS

Perfluorooctane sulfonic acid

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Category
pfas · Long-chain PFAS
Record
specific compound · restricted
Identifiers
CAS 1763-23-1 · C8HF17O3S
Aliases
PFOS, Perfluorooctanesulfonic acid

Long-chain perfluoroalkyl substance. Immune, developmental, and metabolic signals are seed hypotheses. They are not summed into one hazard number.

Flags: environmental chemical · legacy

Phase-1 numbers are seed hypotheses. They are not curated consensus, not a toxicity total, and not a statement of human risk. Association is not written as causation.

REP · Reproductive endocrinology

Fertility

FERTILITY · group GONADAL_FUNCTION · Gonadal function · scorable

Fertility. Mechanism node for evidence linkage. A row here is not itself a finding.

Score +3Disruptive signalLow confidenceH2seed hypothesisreview v1

Reproductive domain seed at +3, the lower end of +3 to +4. This is not an estrogen-receptor assignment.

Placed on fertility because a single receptor mechanism is not established in this seed.

Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

  • Insufficient human evidence

No evidence finding is linked yet.

Score history
  • 2026-10-03: — → +3. Initial seed hypothesis, version 1. Not a curated consensus.

DEV · Developmental endocrinology

Neurodevelopment

NEURODEVELOPMENT · group NEURODEVELOPMENT · Developmental differentiation · scorable

Neurodevelopment. Mechanism node for evidence linkage. A row here is not itself a finding.

Score +4Disruptive signalLow confidenceH3seed hypothesisreview v1

Developmental seed hypothesis. Not a claim of a single completed causal pathway in humans.

Neurodevelopment node, separate from thyroid-specific compounds such as TFA.

Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

    No evidence finding is linked yet.

    Score history
    • 2026-10-03: — → +4. Initial seed hypothesis, version 1. Not a curated consensus.

    IMM · Immunology and immunoendocrinology

    Antibody response

    ANTIBODY_RESPONSE · group ANTIBODY_RESPONSE · Adaptive immunity · scorable

    Antibody response. Mechanism node for evidence linkage. A row here is not itself a finding.

    Score +4Disruptive signalModerate confidenceH3seed hypothesisreview v1

    Reduced antibody response, including vaccine-response literature, is the immune seed. Association is not restated as proven causation for every exposure.

    Antibody and vaccine response share one cluster.

    Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → +4. Initial seed hypothesis, version 1. Not a curated consensus.

      MET · Systemic metabolism

      PPAR-alpha

      PPAR_ALPHA · group NUCLEAR_RECEPTOR_LIPID · Lipid handling · scorable

      PPAR-alpha. Mechanism node for evidence linkage. A row here is not itself a finding.

      Score +4Disruptive signalModerate confidenceH2seed hypothesisreview v1

      PPAR-alpha activity is a biological effect with metabolic concern. It is not itself a diagnosis of diabetes.

      Nuclear-receptor lipid cluster.

      Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

        No evidence finding is linked yet.

        Score history
        • 2026-10-03: — → +4. Initial seed hypothesis, version 1. Not a curated consensus.

        MITO · Mitochondrial bioenergetics

        ATP production

        ATP_PRODUCTION · group BIOENERGETIC_OUTPUT · Bioenergetic output · scorable

        ATP production. Mechanism node for evidence linkage. A row here is not itself a finding.

        Score +3Disruptive signalLow confidenceH1seed hypothesisreview v1

        Mitochondrial seed at +3.

        Bioenergetic output only.

        Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

        • Insufficient human evidence
        • Dose relevance uncertain

        No evidence finding is linked yet.

        Score history
        • 2026-10-03: — → +3. Initial seed hypothesis, version 1. Not a curated consensus.

        REDOX · Redox and cellular stress

        ROS (total)

        ROS_TOTAL · group ROS_GENERATION · Reactive species · scorable

        ROS (total). Mechanism node for evidence linkage. A row here is not itself a finding.

        Score +3Disruptive signalLow confidenceH1seed hypothesisreview v1

        Redox seed at +3.

        ROS cluster only.

        Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

        • Insufficient human evidence

        No evidence finding is linked yet.

        Score history
        • 2026-10-03: — → +3. Initial seed hypothesis, version 1. Not a curated consensus.