EDCtox

Mechanistic evidence atlas. Scores summarise biological direction and magnitude. They are not a toxicity rank or a human-risk number.

Compounds

TFA

Trifluoroacetic acid

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Category
industrial chemical · Ultra-short-chain fluorinated acid
Record
specific compound · unknown
Identifiers
CAS 76-05-1 · C2HF3O2
Aliases
Trifluoroacetic acid

Highly persistent fluorinated acid and a terminal degradation product of some fluorinated substances. This seed does not treat TFA as a classical estrogenic compound.

Flags: environmental chemical

Phase-1 numbers are seed hypotheses. They are not curated consensus, not a toxicity total, and not a statement of human risk. Association is not written as causation.

REP · Reproductive endocrinology

ER-alpha agonism

ER_ALPHA_AGONISM · group ESTROGEN_RECEPTOR · Estrogen receptor axis · scorable

Estrogen receptor alpha agonism or activation. A binding or reporter result is not itself a human disease claim.

Score not quantifiedDirection uncertainLow confidenceH0seed hypothesisreview v1

TFA is not seeded as a classical estrogenic compound.

Unscored on purpose so an empty estrogen cell is explicit.

Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

    No evidence finding is linked yet.

    Score history
    • 2026-10-03: — → —. Initial seed hypothesis, version 1. Not a curated consensus.

    DEV · Developmental endocrinology

    Thyroid-dependent brain development

    THYROID_DEPENDENT_BRAIN_DEVELOPMENT · group THYROID_DEVELOPMENT · Developmental differentiation · scorable

    Thyroid-dependent brain development. Mechanism node for evidence linkage. A row here is not itself a finding.

    Score +3Disruptive signalLow confidenceH2seed hypothesisreview v1

    Pathway: TFA thyroid developmental chain. Not summed with other domains.

    Developmental seed at +3 through thyroid-dependent brain development.

    Linked to the thyroid pathway and not added to the neuroendocrine score.

    Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

    • Insufficient human evidence
    • Developmental relevance uncertain

    No evidence finding is linked yet.

    Score history
    • 2026-10-03: — → +3. Initial seed hypothesis, version 1. Not a curated consensus.

    NEUROENDO · Neuroendocrine, HPA, and circadian

    Thyroid hormone (T4/T3)

    THYROID_HORMONE · group THYROID_AXIS · Thyroid axis · scorable

    Circulating and tissue thyroid hormone signalling. Added so thyroid-active compounds are not forced into an estrogen-receptor mechanism.

    Score +4Disruptive signalLow confidenceH2seed hypothesisreview v1

    Pathway: TFA thyroid developmental chain. Not summed with other domains.

    Thyroid-axis concern is the neuroendocrine seed. Human causality is below an established clinical or environmental H4.

    Thyroid hormone cluster. Not ER-alpha.

    Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

    • Insufficient human evidence

    No evidence finding is linked yet.

    Score history
    • 2026-10-03: — → +4. Initial seed hypothesis, version 1. Not a curated consensus.