EDCtox

Mechanistic evidence atlas. Scores summarise biological direction and magnitude. They are not a toxicity rank or a human-risk number.

Compounds

DEHP

Bis(2-ethylhexyl) phthalate

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Category
plasticiser · Phthalate plasticiser
Record
specific compound · restricted
Identifiers
CAS 117-81-7 · C24H38O4
Aliases
Bis(2-ethylhexyl) phthalate, DEHP, Diethylhexyl phthalate

Phthalate plasticiser. Anti-androgenic developmental effects and metabolic signals are seed hypotheses, not a single toxicity total.

Flags: environmental chemical

Phase-1 numbers are seed hypotheses. They are not curated consensus, not a toxicity total, and not a statement of human risk. Association is not written as causation.

REP · Reproductive endocrinology

Testosterone

TESTOSTERONE · group STEROIDOGENESIS · Steroidogenic enzymes · scorable

Testosterone. Mechanism node for evidence linkage. A row here is not itself a finding.

Score +4Disruptive signalModerate confidenceH3seed hypothesisreview v1

Disruption is reduced testicular testosterone synthesis, not an increase in testosterone.

Steroidogenesis cluster. Enzyme rows are not added on top of the hormone-level row.

Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

    No evidence finding is linked yet.

    Score history
    • 2026-10-03: — → +4. Initial seed hypothesis, version 1. Not a curated consensus.

    DEV · Developmental endocrinology

    Anogenital distance

    ANOGENITAL_DISTANCE · group DEVELOPMENTAL_MORPHOLOGY · Developmental differentiation · scorable

    Anogenital distance. Mechanism node for evidence linkage. A row here is not itself a finding.

    Score +4Disruptive signalModerate confidenceH3seed hypothesisreview v1

    Shorter anogenital distance is the developmental morphological signal in this seed.

    Distinct from the adult steroidogenesis cluster.

    Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → +4. Initial seed hypothesis, version 1. Not a curated consensus.

      MET · Systemic metabolism

      Insulin resistance

      INSULIN_RESISTANCE · group INSULIN_SIGNALING · Insulin signalling pathway · scorable

      Impaired insulin action at target tissues. A mechanistic insulin-signalling change is not automatically a diagnosis of diabetes.

      Score +3Disruptive signalLow confidenceH2seed hypothesisreview v1

      Metabolic seed uses +3, the lower end of the discussed +3 to +4 range.

      Not added to the reproductive score.

      Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      • Insufficient human evidence

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → +3. Initial seed hypothesis, version 1. Not a curated consensus.

      MITO · Mitochondrial bioenergetics

      ATP production

      ATP_PRODUCTION · group BIOENERGETIC_OUTPUT · Bioenergetic output · scorable

      ATP production. Mechanism node for evidence linkage. A row here is not itself a finding.

      Score +3Disruptive signalLow confidenceH1seed hypothesisreview v1

      Mitochondrial seed at +3.

      Not a reorganization-energy claim.

      Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      • Insufficient human evidence
      • Dose relevance uncertain

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → +3. Initial seed hypothesis, version 1. Not a curated consensus.

      REDOX · Redox and cellular stress

      ROS (total)

      ROS_TOTAL · group ROS_GENERATION · Reactive species · scorable

      ROS (total). Mechanism node for evidence linkage. A row here is not itself a finding.

      Score +3Disruptive signalLow confidenceH1seed hypothesisreview v1

      Redox seed at +3.

      ROS cluster only.

      Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      • Insufficient human evidence

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → +3. Initial seed hypothesis, version 1. Not a curated consensus.