EDCtox

Mechanistic evidence atlas. Scores summarise biological direction and magnitude. They are not a toxicity rank or a human-risk number.

Compounds

DEHP

Bis(2-ethylhexyl) phthalate

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Category
plasticiser · Phthalate plasticiser
Record
specific compound · restricted
Identifiers
CAS 117-81-7 · C24H38O4
Aliases
Bis(2-ethylhexyl) phthalate, DEHP, Diethylhexyl phthalate

Phthalate plasticiser. Anti-androgenic developmental effects and metabolic signals are seed hypotheses, not a single toxicity total.

Flags: environmental chemical

Phase-1 numbers are seed hypotheses. They are not curated consensus, not a toxicity total, and not a statement of human risk. Association is not written as causation.
REP
Reproductive
+4
DEV
Developmental
+4
NEUROENDO
Neuroendocrine / HPA
—
IMM
Immune
—
MET
Metabolic
+3
MITO
Mitochondrial
+3
REDOX
Redox
+3

Left of the centre line is protective or restorative. Right is disruptive. Physiological activity is labelled and is not drawn as disruption. Domains are not added together.

REP · Reproductive

+4

Headline +4 is the strongest independent cluster (STEROIDOGENESIS: Testosterone). Other clusters and child mechanisms were not added. Human relevance is the relevance of the headline cluster, not the maximum relevance anywhere in the domain, and it is not multiplied into the score. No curated scientific findings are linked yet. The number is a seed assessment, not a literature count. Direction DISRUPTIVE. Confidence MODERATE. Human relevance H3. Supporting findings 0. Contradictory findings 0. Curation SEED_HYPOTHESIS.

Direction: Disruptive signal
Confidence: Moderate
Human relevance: H3 · substantial human observation plus biology
Findings 0 supporting / 0 contradictory · 0 capped

DEV · Developmental

+4

Headline +4 is the strongest independent cluster (DEVELOPMENTAL_MORPHOLOGY: Anogenital distance). Other clusters and child mechanisms were not added. Human relevance is the relevance of the headline cluster, not the maximum relevance anywhere in the domain, and it is not multiplied into the score. No curated scientific findings are linked yet. The number is a seed assessment, not a literature count. Direction DISRUPTIVE. Confidence MODERATE. Human relevance H3. Supporting findings 0. Contradictory findings 0. Curation SEED_HYPOTHESIS.

Direction: Disruptive signal
Confidence: Moderate
Human relevance: H3 · substantial human observation plus biology
Findings 0 supporting / 0 contradictory · 0 capped

NEUROENDO · Neuroendocrine / HPA

—

No quantitative mechanistic score is stored for this domain.

Direction: Direction uncertain
Confidence: —
Human relevance: —
Findings 0 supporting / 0 contradictory · 0 capped

IMM · Immune

—

No quantitative mechanistic score is stored for this domain.

Direction: Direction uncertain
Confidence: —
Human relevance: —
Findings 0 supporting / 0 contradictory · 0 capped

MET · Metabolic

+3

Headline +3 is the strongest independent cluster (INSULIN_SIGNALING: Insulin resistance). Other clusters and child mechanisms were not added. Human relevance is the relevance of the headline cluster, not the maximum relevance anywhere in the domain, and it is not multiplied into the score. No curated scientific findings are linked yet. The number is a seed assessment, not a literature count. Direction DISRUPTIVE. Confidence LOW. Human relevance H2. Supporting findings 0. Contradictory findings 0. Curation SEED_HYPOTHESIS.

Direction: Disruptive signal
Confidence: Low
Human relevance: H2 · strong experimental, limited human
Findings 0 supporting / 0 contradictory · 0 capped

MITO · Mitochondrial

+3

Headline +3 is the strongest independent cluster (BIOENERGETIC_OUTPUT: ATP production). Other clusters and child mechanisms were not added. Human relevance is the relevance of the headline cluster, not the maximum relevance anywhere in the domain, and it is not multiplied into the score. No curated scientific findings are linked yet. The number is a seed assessment, not a literature count. Direction DISRUPTIVE. Confidence LOW. Human relevance H1. Supporting findings 0. Contradictory findings 0. Curation SEED_HYPOTHESIS.

Direction: Disruptive signal
Confidence: Low
Human relevance: H1 · mechanistic, cellular, or high-dose animal
Findings 0 supporting / 0 contradictory · 0 capped

REDOX · Redox

+3

Headline +3 is the strongest independent cluster (ROS_GENERATION: ROS (total)). Other clusters and child mechanisms were not added. Human relevance is the relevance of the headline cluster, not the maximum relevance anywhere in the domain, and it is not multiplied into the score. No curated scientific findings are linked yet. The number is a seed assessment, not a literature count. Direction DISRUPTIVE. Confidence LOW. Human relevance H1. Supporting findings 0. Contradictory findings 0. Curation SEED_HYPOTHESIS.

Direction: Disruptive signal
Confidence: Low
Human relevance: H1 · mechanistic, cellular, or high-dose animal
Findings 0 supporting / 0 contradictory · 0 capped