EDCtox

Mechanistic evidence atlas. Scores summarise biological direction and magnitude. They are not a toxicity rank or a human-risk number.

Compounds

Methylphenidate

Methylphenidate

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Category
pharmaceutical · Stimulant
Record
specific compound · in current use
Identifiers
CAS 113-45-1
Aliases
MPH

Stimulant. Appetite and growth effects at therapeutic doses are recorded separately from experimental mitochondrial findings, whose relevance at therapeutic human doses is uncertain.

Flags: pharmaceutical

Phase-1 numbers are seed hypotheses. They are not curated consensus, not a toxicity total, and not a statement of human risk. Association is not written as causation.

REP · Reproductive endocrinology

Fertility

FERTILITY · group GONADAL_FUNCTION · Gonadal function · scorable

Fertility. Mechanism node for evidence linkage. A row here is not itself a finding.

Score +2Direction uncertainVery low confidenceH0seed hypothesisreview v1

Reproductive seed at +2 is explicitly uncertain. It is not an established fertility effect.

Very low confidence. Absence of a stronger score is not evidence of safety or of harm.

Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

  • Insufficient human evidence
  • Developmental relevance uncertain

No evidence finding is linked yet.

Score history
  • 2026-10-03: — → +2. Initial seed hypothesis, version 1. Not a curated consensus.

DEV · Developmental endocrinology

Growth

GROWTH · group GROWTH · Puberty and growth · scorable

Growth. Mechanism node for evidence linkage. A row here is not itself a finding.

Score +2Disruptive signalModerate confidenceH3seed hypothesisreview v1

Exposure: therapeutic · childhood · Children prescribed methylphenidate

Slower growth during therapeutic paediatric use is a clinical effect. The score is the lower end of +2 to +3. It is not a mitochondrial finding.

Growth node at therapeutic childhood exposure.

Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

    No evidence finding is linked yet.

    Score history
    • 2026-10-03: — → +2. Initial seed hypothesis, version 1. Not a curated consensus.

    NEUROENDO · Neuroendocrine, HPA, and circadian

    Hypothalamic appetite signalling

    APPETITE_HYPOTHALAMUS · group APPETITE · Circadian timing · scorable

    Hypothalamic appetite signalling. Mechanism node for evidence linkage. A row here is not itself a finding.

    Score +3Context-dependentHigh confidenceH4seed hypothesisreview v1

    Exposure: therapeutic · childhood · Children prescribed methylphenidate

    Reduced appetite is an established clinical effect at therapeutic doses. It is pharmacology, not evidence of neuronal mitochondrial injury.

    Appetite cluster. Separate from complex I or ATP rows.

    Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → +3. Initial seed hypothesis, version 1. Not a curated consensus.

      MET · Systemic metabolism

      Insulin resistance

      INSULIN_RESISTANCE · group INSULIN_SIGNALING · Insulin signalling pathway · scorable

      Impaired insulin action at target tissues. A mechanistic insulin-signalling change is not automatically a diagnosis of diabetes.

      Score +2Disruptive signalLow confidenceH1seed hypothesisreview v1

      Metabolic seed at +2. Not the appetite effect.

      Insulin-signalling cluster.

      Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      • Insufficient human evidence

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → +2. Initial seed hypothesis, version 1. Not a curated consensus.

      MITO · Mitochondrial bioenergetics

      ATP production

      ATP_PRODUCTION · group BIOENERGETIC_OUTPUT · Bioenergetic output · scorable

      ATP production. Mechanism node for evidence linkage. A row here is not itself a finding.

      Score +2Disruptive signalLow confidenceH1seed hypothesisreview v1

      Experimental mitochondrial seed at +2, the lower end of +2 to +3. Therapeutic-dose human relevance is uncertain.

      Must not be read as the established growth or appetite effect.

      Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      • Insufficient human evidence
      • Dose relevance uncertain

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → +2. Initial seed hypothesis, version 1. Not a curated consensus.

      REDOX · Redox and cellular stress

      ROS (total)

      ROS_TOTAL · group ROS_GENERATION · Reactive species · scorable

      ROS (total). Mechanism node for evidence linkage. A row here is not itself a finding.

      Score +2Disruptive signalLow confidenceH1seed hypothesisreview v1

      Experimental redox seed at +2, the lower end of +2 to +3.

      Therapeutic-dose human relevance is uncertain.

      Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      • Insufficient human evidence
      • Dose relevance uncertain

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → +2. Initial seed hypothesis, version 1. Not a curated consensus.