EDCtox

Mechanistic evidence atlas. Scores summarise biological direction and magnitude. They are not a toxicity rank or a human-risk number.

Compounds

Olanzapine

Olanzapine

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Category
pharmaceutical · Atypical antipsychotic
Record
specific compound · in current use
Identifiers
CAS 132539-06-1
Aliases
—

Atypical antipsychotic. Metabolic disruption at therapeutic doses is recorded separately from dopamine pharmacology and from mitochondrial hypotheses.

Flags: pharmaceutical

Phase-1 numbers are seed hypotheses. They are not curated consensus, not a toxicity total, and not a statement of human risk. Association is not written as causation.

REP · Reproductive endocrinology

Prolactin

PROLACTIN · group HPG_AXIS · Hypothalamic–pituitary–gonadal axis · scorable

Prolactin secretion and signalling. Antipsychotic D2 antagonism can raise prolactin; that pharmacology is not the same as a metabolic effect.

Score +2Disruptive signalModerate confidenceH3seed hypothesisreview v1

Prolactin elevation occurs but is seeded below risperidone.

HPG-axis cluster. GnRH is not scored again.

Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

    No evidence finding is linked yet.

    Score history
    • 2026-10-03: — → +2. Initial seed hypothesis, version 1. Not a curated consensus.

    DEV · Developmental endocrinology

    Developmental metabolic programming

    DEVELOPMENTAL_METABOLIC_PROGRAMMING · group DEVELOPMENTAL_PROGRAMMING · Developmental programming · scorable

    Developmental metabolic programming. Mechanism node for evidence linkage. A row here is not itself a finding.

    Score +2Disruptive signalLow confidenceH1seed hypothesisreview v1

    Developmental seed at +2. Pregnancy and childhood evidence is not established here.

    Not the adult metabolic score.

    Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

    • Insufficient human evidence
    • Developmental relevance uncertain

    No evidence finding is linked yet.

    Score history
    • 2026-10-03: — → +2. Initial seed hypothesis, version 1. Not a curated consensus.

    NEUROENDO · Neuroendocrine, HPA, and circadian

    Dopamine

    DOPAMINE · group DOPAMINE · HPA axis · scorable

    Dopamine. Mechanism node for evidence linkage. A row here is not itself a finding.

    Score +3Context-dependentHigh confidenceH4seed hypothesisreview v1

    D2 antagonism is intended antipsychotic pharmacology. The signed score is not a claim that dopamine blockade is solely an adverse endocrine effect.

    Kept separate from prolactin and from insulin resistance.

    Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → +3. Initial seed hypothesis, version 1. Not a curated consensus.

      MET · Systemic metabolism

      Insulin resistance

      INSULIN_RESISTANCE · group INSULIN_SIGNALING · Insulin signalling pathway · scorable

      Impaired insulin action at target tissues. A mechanistic insulin-signalling change is not automatically a diagnosis of diabetes.

      Score +4Disruptive signalHigh confidenceH4seed hypothesisreview v1

      Exposure: therapeutic · adult · Adults prescribed olanzapine

      Pathway: Olanzapine metabolic, mitochondrial, and redox chain. Not summed with other domains.

      Substantial insulin resistance is recorded at therapeutic adult use. This is a clinical association, not a claim that every exposed person develops diabetes.

      Headline metabolic cluster at therapeutic dose.

      Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

        No evidence finding is linked yet.

        Score history
        • 2026-10-03: — → +4. Initial seed hypothesis, version 1. Not a curated consensus.

        IRS1

        IRS1 · group INSULIN_SIGNALING · Insulin signalling pathway · scorable

        IRS1. Mechanism node for evidence linkage. A row here is not itself a finding.

        Score +2Disruptive signalLow confidenceH1seed hypothesisreview v1

        Pathway: Olanzapine metabolic, mitochondrial, and redox chain. Not summed with other domains.

        Signalling node in the same insulin cluster. Not an extra metabolic point.

        Capped with insulin resistance.

        Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

        • Insufficient human evidence

        No evidence finding is linked yet.

        Score history
        • 2026-10-03: — → +2. Initial seed hypothesis, version 1. Not a curated consensus.

        MITO · Mitochondrial bioenergetics

        ATP production

        ATP_PRODUCTION · group BIOENERGETIC_OUTPUT · Bioenergetic output · scorable

        ATP production. Mechanism node for evidence linkage. A row here is not itself a finding.

        Score +3Disruptive signalLow confidenceH1seed hypothesisreview v1

        Pathway: Olanzapine metabolic, mitochondrial, and redox chain. Not summed with other domains.

        Mitochondrial seed at +3. Human therapeutic-dose relevance is not established.

        Tagged on the same pathway as insulin resistance so the profile can show the chain without summing it.

        Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

        • Insufficient human evidence
        • Dose relevance uncertain

        No evidence finding is linked yet.

        Score history
        • 2026-10-03: — → +3. Initial seed hypothesis, version 1. Not a curated consensus.

        REDOX · Redox and cellular stress

        ROS (total)

        ROS_TOTAL · group ROS_GENERATION · Reactive species · scorable

        ROS (total). Mechanism node for evidence linkage. A row here is not itself a finding.

        Score +3Disruptive signalLow confidenceH1seed hypothesisreview v1

        Pathway: Olanzapine metabolic, mitochondrial, and redox chain. Not summed with other domains.

        Redox seed at +3 under experimental and mechanistic discussion.

        Same pathway tag as the metabolic and mitochondrial rows. Not added to them.

        Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

        • Insufficient human evidence

        No evidence finding is linked yet.

        Score history
        • 2026-10-03: — → +3. Initial seed hypothesis, version 1. Not a curated consensus.