EDCtox

Mechanistic evidence atlas. Scores summarise biological direction and magnitude. They are not a toxicity rank or a human-risk number.

Compounds

Rotenone

Rotenone

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Category
pesticide · Complex I inhibitor
Record
specific compound · unknown
Identifiers
CAS 83-79-4
Aliases
—

Mitochondrial complex I inhibitor, used historically as a pesticide and piscicide. Complex I disruption is not an estrogen-receptor effect.

Flags: environmental chemical

Phase-1 numbers are seed hypotheses. They are not curated consensus, not a toxicity total, and not a statement of human risk. Association is not written as causation.

MITO · Mitochondrial bioenergetics

ETC complex I

ETC_COMPLEX_I · group ETC_COMPLEX_I · Electron transport complexes · scorable

NADH:ubiquinone oxidoreductase. Rotenone and some redox-cycling toxicants act here. Do not infer complex II effects from complex I data.

Score +4Disruptive signalHigh confidenceH1seed hypothesisreview v1

Complex I inhibition is the established experimental mechanism.

Not complex II. Not an estrogen-receptor effect.

Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

  • Insufficient human evidence
  • Dose relevance uncertain

No evidence finding is linked yet.

Score history
  • 2026-10-03: — → +4. Initial seed hypothesis, version 1. Not a curated consensus.

REDOX · Redox and cellular stress

ROS (total)

ROS_TOTAL · group ROS_GENERATION · Reactive species · scorable

ROS (total). Mechanism node for evidence linkage. A row here is not itself a finding.

Score +4Disruptive signalHigh confidenceH1seed hypothesisreview v1

Substantial ROS generation accompanies complex I blockade in experimental systems.

Separate domain from complex I. Not summed.

Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

  • Insufficient human evidence

No evidence finding is linked yet.

Score history
  • 2026-10-03: — → +4. Initial seed hypothesis, version 1. Not a curated consensus.