EDCtox

Mechanistic evidence atlas. Scores summarise biological direction and magnitude. They are not a toxicity rank or a human-risk number.

Compounds

Valproate

Valproic acid

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Category
pharmaceutical · Antiseizure medication
Record
specific compound · in current use
Identifiers
CAS 99-66-1
Aliases
Sodium valproate, Valproic acid

Antiseizure medication. Developmental toxicity is established and is largely not specifically endocrine. Metabolic and mitochondrial signals are recorded separately.

Flags: pharmaceutical

Phase-1 numbers are seed hypotheses. They are not curated consensus, not a toxicity total, and not a statement of human risk. Association is not written as causation.

REP · Reproductive endocrinology

Testosterone

TESTOSTERONE · group STEROIDOGENESIS · Steroidogenic enzymes · scorable

Testosterone. Mechanism node for evidence linkage. A row here is not itself a finding.

Score +4Disruptive signalModerate confidenceH3seed hypothesisreview v1

Reproductive endocrine disruption, including androgen and ovulatory associations, is seeded at +4. Direction of each hormone is not uniform and is not reduced to one receptor.

Domain headline. PCOS is an outcome row, not this mechanism.

Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

    No evidence finding is linked yet.

    Score history
    • 2026-10-03: — → +4. Initial seed hypothesis, version 1. Not a curated consensus.

    DEV · Developmental endocrinology

    Neurodevelopment

    NEURODEVELOPMENT · group NEURODEVELOPMENT · Developmental differentiation · scorable

    Neurodevelopment. Mechanism node for evidence linkage. A row here is not itself a finding.

    Score +4Disruptive signalHigh confidenceH4seed hypothesisreview v1

    Developmental toxicity including neural-tube defects is established. Much of it is not specifically endocrine.

    Scored on neurodevelopment so a non-endocrine teratogenic effect is not mislabelled as estrogenic.

    Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → +4. Initial seed hypothesis, version 1. Not a curated consensus.

      MET · Systemic metabolism

      Insulin resistance

      INSULIN_RESISTANCE · group INSULIN_SIGNALING · Insulin signalling pathway · scorable

      Impaired insulin action at target tissues. A mechanistic insulin-signalling change is not automatically a diagnosis of diabetes.

      Score +4Disruptive signalModerate confidenceH3seed hypothesisreview v1

      Weight gain and insulin-resistance associations during therapeutic use.

      Metabolic cluster, separate from teratogenicity.

      Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

        No evidence finding is linked yet.

        Score history
        • 2026-10-03: — → +4. Initial seed hypothesis, version 1. Not a curated consensus.

        MITO · Mitochondrial bioenergetics

        ATP production

        ATP_PRODUCTION · group BIOENERGETIC_OUTPUT · Bioenergetic output · scorable

        ATP production. Mechanism node for evidence linkage. A row here is not itself a finding.

        Score +3Disruptive signalLow confidenceH1seed hypothesisreview v1

        Mitochondrial seed at +3.

        Not inferred from the teratogenic outcome alone.

        Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

        • Insufficient human evidence
        • Dose relevance uncertain

        No evidence finding is linked yet.

        Score history
        • 2026-10-03: — → +3. Initial seed hypothesis, version 1. Not a curated consensus.

        REDOX · Redox and cellular stress

        ROS (total)

        ROS_TOTAL · group ROS_GENERATION · Reactive species · scorable

        ROS (total). Mechanism node for evidence linkage. A row here is not itself a finding.

        Score +3Disruptive signalLow confidenceH1seed hypothesisreview v1

        Redox seed at +3.

        ROS cluster only.

        Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

        • Insufficient human evidence

        No evidence finding is linked yet.

        Score history
        • 2026-10-03: — → +3. Initial seed hypothesis, version 1. Not a curated consensus.