Insulin resistance
INSULIN_RESISTANCE
Impaired insulin action at target tissues. A mechanistic insulin-signalling change is not automatically a diagnosis of diabetes.
No claims yet. The supporting sentence stays unlisted. Claim count does not change a score.
Identity
- Domain
- MET · Systemic metabolism
- Family
- No family
- Aggregation group
- INSULIN_SIGNALING
- Score policy
- scorable
Hierarchy
Parent: Insulin signalling pathway
No child mechanisms.
Siblings: Insulin secretion, Beta-cell function, Fasting insulin, Hyperinsulinemia, Insulin receptor, IRS1, IRS2, PI3K, AKT, GLUT4, GLUT2, Hepatic glucose production, FOXO1, PEPCK, Glucose-6-phosphatase, Glycogen metabolism, Glycolysis, TCA cycle, Glucose tolerance
External mappings
No external mapping is stored.
Assessments
These are synthesized judgments. They are separate from the claims below, and the claim count does not set the score.
- BPA+4
Disruptive signal · Moderate confidence · H3 · substantial human observation plus biology · seed hypothesis
- DEHP+3
Disruptive signal · Low confidence · H2 · strong experimental, limited human · seed hypothesis
- Fluoxetine+2
Disruptive signal · Low confidence · H2 · strong experimental, limited human · seed hypothesis
- Melatoninnot quantified
Context-dependent · Very low confidence · H1 · mechanistic, cellular, or high-dose animal · seed hypothesis
- Methylphenidate+2
Disruptive signal · Low confidence · H1 · mechanistic, cellular, or high-dose animal · seed hypothesis
- Olanzapine+4
Disruptive signal · High confidence · H4 · established at relevant human exposure · seed hypothesis
- Risperidone+3
Disruptive signal · Moderate confidence · H3 · substantial human observation plus biology · seed hypothesis
- Valproate+4
Disruptive signal · Moderate confidence · H3 · substantial human observation plus biology · seed hypothesis
Claims
- Claims
- 0
- Papers
- 0
- Curator verified
- 0
- Candidate mappings
- 0
- Directness:
- None recorded
- Species:
- None recorded
- Tissue:
- None recorded
- Cell:
- None recorded
No claims yet.