Mechanisms
Every mechanism in the ontology, including those with no claims and no assessment. A claim count is not a score. Machine-extracted claims stay labeled, and a candidate mapping is not a curator-verified one.
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| Mechanism | Domain | Family | Parent | Group | Policy | Assessed | Claims | Verified | Direct | Inferred | Status |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Estrogen receptor axisREP_ESTROGEN_RECEPTOR | REP | — | — | REP_ESTROGEN_RECEPTOR | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Androgen receptor axisREP_ANDROGEN_RECEPTOR | REP | — | — | REP_ANDROGEN_RECEPTOR | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Steroidogenic enzymesREP_STEROIDOGENESIS | REP | — | — | REP_STEROIDOGENESIS | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Hypothalamic–pituitary–gonadal axisREP_HPG | REP | — | — | REP_HPG | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Gonadal functionREP_GONADAL | REP | — | — | REP_GONADAL | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| ER-alpha agonismER_ALPHA_AGONISM | REP | — | Estrogen receptor axis | ESTROGEN_RECEPTOR | scorable | 4 | 0 | 0 | 0 | 0 | No claims yet |
| ER-alpha antagonismER_ALPHA_ANTAGONISM | REP | — | Estrogen receptor axis | ESTROGEN_RECEPTOR | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| ER-beta agonismER_BETA_AGONISM | REP | — | Estrogen receptor axis | ESTROGEN_RECEPTOR | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| ER-beta antagonismER_BETA_ANTAGONISM | REP | — | Estrogen receptor axis | ESTROGEN_RECEPTOR | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| GPER signallingGPER_SIGNALING | REP | — | Estrogen receptor axis | ESTROGEN_RECEPTOR | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Androgen receptor agonismANDROGEN_RECEPTOR_AGONISM | REP | — | Androgen receptor axis | ANDROGEN_RECEPTOR | scorable | 1 | 0 | 0 | 0 | 0 | No claims yet |
| Androgen receptor antagonismANDROGEN_RECEPTOR_ANTAGONISM | REP | — | Androgen receptor axis | ANDROGEN_RECEPTOR | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Progesterone receptorPROGESTERONE_RECEPTOR | REP | — | Steroidogenic enzymes | PROGESTERONE_SIGNALING | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Aromatase (CYP19A1)AROMATASE_CYP19A1 | REP | — | Steroidogenic enzymes | STEROIDOGENESIS | scorable | 0 | 21 compounds | 0 | 0 | 1 | Candidate mappings only |
| StARSTAR | REP | — | Steroidogenic enzymes | STEROIDOGENESIS | scorable | 0 | 11 compounds | 0 | 0 | 1 | Candidate mappings only |
| CYP11A1CYP11A1 | REP | — | Steroidogenic enzymes | STEROIDOGENESIS | scorable | 0 | 11 compounds | 0 | 0 | 1 | Candidate mappings only |
| CYP17A1CYP17A1 | REP | — | Steroidogenic enzymes | STEROIDOGENESIS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| 3β-HSDHSD3B | REP | — | Steroidogenic enzymes | STEROIDOGENESIS | scorable | 0 | 21 compounds | 0 | 0 | 1 | Candidate mappings only |
| 17β-HSDHSD17B | REP | — | Steroidogenic enzymes | STEROIDOGENESIS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| GnRHGNRH | REP | — | Hypothalamic–pituitary–gonadal axis | HPG_AXIS | scorable | 1 | 0 | 0 | 0 | 0 | No claims yet |
| KisspeptinKISSPEPTIN | REP | — | Hypothalamic–pituitary–gonadal axis | HPG_AXIS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| GnIHGNIH | REP | — | Hypothalamic–pituitary–gonadal axis | HPG_AXIS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| LHLH | REP | — | Hypothalamic–pituitary–gonadal axis | HPG_AXIS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| FSHFSH | REP | — | Hypothalamic–pituitary–gonadal axis | HPG_AXIS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| ProlactinPROLACTIN | REP | — | Hypothalamic–pituitary–gonadal axis | HPG_AXIS | scorable | 2 | 0 | 0 | 0 | 0 | No claims yet |
| TestosteroneTESTOSTERONE | REP | — | Steroidogenic enzymes | STEROIDOGENESIS | scorable | 2 | 0 | 0 | 0 | 0 | No claims yet |
| EstradiolESTRADIOL | REP | — | Steroidogenic enzymes | STEROIDOGENESIS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| ProgesteronePROGESTERONE | REP | — | Steroidogenic enzymes | PROGESTERONE_SIGNALING | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| DHTDHT | REP | — | Androgen receptor axis | ANDROGEN_RECEPTOR | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| SpermatogenesisSPERMATOGENESIS | REP | — | Gonadal function | GONADAL_FUNCTION | scorable | 0 | 11 compounds | 0 | 0 | 0 | Candidate mappings only |
| OogenesisOOGENESIS | REP | — | Gonadal function | GONADAL_FUNCTION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Ovarian follicle reserveOVARIAN_FOLLICLE_RESERVE | REP | — | Gonadal function | GONADAL_FUNCTION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| OvulationOVULATION | REP | — | Gonadal function | GONADAL_FUNCTION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| FertilityFERTILITY | REP | — | Gonadal function | GONADAL_FUNCTION | scorable | 3 | 0 | 0 | 0 | 0 | No claims yet |
| Sexual differentiationSEXUAL_DIFFERENTIATION | REP | — | Gonadal function | GONADAL_FUNCTION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| PlacentaDEV_PLACENTA | DEV | — | — | DEV_PLACENTA | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Fetal gonadDEV_FETAL_GONAD | DEV | — | — | DEV_FETAL_GONAD | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Developmental differentiationDEV_DIFFERENTIATION | DEV | — | — | DEV_DIFFERENTIATION | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Puberty and growthDEV_PUBERTY_GROWTH | DEV | — | — | DEV_PUBERTY_GROWTH | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Developmental programmingDEV_EPIGENETIC | DEV | — | — | DEV_EPIGENETIC | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Placental signallingPLACENTAL_SIGNALING | DEV | — | Placenta | PLACENTA | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Placental steroidogenesisPLACENTAL_STEROIDOGENESIS | DEV | — | Placenta | PLACENTA | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Fetal gonadFETAL_GONAD | DEV | — | Fetal gonad | FETAL_GONAD | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Fetal Leydig cellFETAL_LEYDIG_CELL | DEV | — | Fetal gonad | FETAL_GONAD | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Fetal ovaryFETAL_OVARY | DEV | — | Fetal gonad | FETAL_OVARY | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Anogenital distanceANOGENITAL_DISTANCE | DEV | — | Developmental differentiation | DEVELOPMENTAL_MORPHOLOGY | scorable | 1 | 0 | 0 | 0 | 0 | No claims yet |
| Brain sexual differentiationBRAIN_SEXUAL_DIFFERENTIATION | DEV | — | Developmental differentiation | DEVELOPMENTAL_MORPHOLOGY | scorable | 1 | 0 | 0 | 0 | 0 | No claims yet |
| Thyroid-dependent brain developmentTHYROID_DEPENDENT_BRAIN_DEVELOPMENT | DEV | — | Developmental differentiation | THYROID_DEVELOPMENT | scorable | 1 | 0 | 0 | 0 | 0 | No claims yet |
| NeurodevelopmentNEURODEVELOPMENT | DEV | — | Developmental differentiation | NEURODEVELOPMENT | scorable | 3 | 0 | 0 | 0 | 0 | No claims yet |
| Puberty timingPUBERTY_TIMING | DEV | — | Puberty and growth | PUBERTY | scorable | 2 | 0 | 0 | 0 | 0 | No claims yet |
| MenarcheMENARCHE | DEV | — | Puberty and growth | PUBERTY | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| GrowthGROWTH | DEV | — | Puberty and growth | GROWTH | scorable | 1 | 0 | 0 | 0 | 0 | No claims yet |
| Epigenetic programmingEPIGENETIC_PROGRAMMING | DEV | — | Developmental programming | EPIGENETIC_PROGRAMMING | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Germline epigeneticsGERMLINE_EPIGENETICS | DEV | — | Developmental programming | EPIGENETIC_PROGRAMMING | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Transgenerational signalTRANSGENERATIONAL_SIGNAL | DEV | — | Developmental programming | EPIGENETIC_PROGRAMMING | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Developmental metabolic programmingDEVELOPMENTAL_METABOLIC_PROGRAMMING | DEV | — | Developmental programming | DEVELOPMENTAL_PROGRAMMING | scorable | 1 | 0 | 0 | 0 | 0 | No claims yet |
| Developmental immune programmingDEVELOPMENTAL_IMMUNE_PROGRAMMING | DEV | — | Developmental programming | DEVELOPMENTAL_PROGRAMMING | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| HPA axisNEU_HPA | NEUROENDO | — | — | NEU_HPA | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Melatonin receptorsNEU_MELATONIN | NEUROENDO | — | — | NEU_MELATONIN | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Circadian timingNEU_CIRCADIAN | NEUROENDO | — | — | NEU_CIRCADIAN | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Thyroid axisNEU_THYROID | NEUROENDO | — | — | NEU_THYROID | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| CRHCRH | NEUROENDO | — | HPA axis | HPA | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| ACTHACTH | NEUROENDO | — | HPA axis | HPA | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| CortisolCORTISOL | NEUROENDO | — | HPA axis | HPA | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Glucocorticoid receptorGLUCOCORTICOID_RECEPTOR | NEUROENDO | — | HPA axis | GLUCOCORTICOID_RECEPTOR | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| HPA axisHPA_AXIS | NEUROENDO | — | HPA axis | HPA | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Sympathetic signallingSYMPATHETIC_SIGNALING | NEUROENDO | — | HPA axis | SYMPATHETIC | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| DopamineDOPAMINE | NEUROENDO | — | HPA axis | DOPAMINE | scorable | 2 | 0 | 0 | 0 | 0 | No claims yet |
| SerotoninSEROTONIN | NEUROENDO | — | HPA axis | SEROTONIN | scorable | 1 | 0 | 0 | 0 | 0 | No claims yet |
| NorepinephrineNOREPINEPHRINE | NEUROENDO | — | HPA axis | NOREPINEPHRINE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Melatonin MT1MELATONIN_MT1 | NEUROENDO | — | Melatonin receptors | MELATONIN_RECEPTOR | scorable | 1 | 0 | 0 | 0 | 0 | No claims yet |
| Melatonin MT2MELATONIN_MT2 | NEUROENDO | — | Melatonin receptors | MELATONIN_RECEPTOR | scorable | 1 | 0 | 0 | 0 | 0 | No claims yet |
| Circadian phaseCIRCADIAN_PHASE | NEUROENDO | — | Circadian timing | CIRCADIAN | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Sleep–wake signallingSLEEP_WAKE_SIGNALING | NEUROENDO | — | Circadian timing | CIRCADIAN | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| SCN signallingSCN_SIGNALING | NEUROENDO | — | Circadian timing | CIRCADIAN | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Hypothalamic appetite signallingAPPETITE_HYPOTHALAMUS | NEUROENDO | — | Circadian timing | APPETITE | scorable | 1 | 0 | 0 | 0 | 0 | No claims yet |
| Leptin signallingLEPTIN_SIGNALING | NEUROENDO | — | Circadian timing | APPETITE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| GH–IGF-1 axisGH_IGF1_AXIS | NEUROENDO | — | HPA axis | GH_IGF1 | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| TSHTSH | NEUROENDO | — | Thyroid axis | THYROID_AXIS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Thyroid hormone (T4/T3)THYROID_HORMONE | NEUROENDO | — | Thyroid axis | THYROID_AXIS | scorable | 1 | 0 | 0 | 0 | 0 | No claims yet |
| Thyroid hormone receptorTHYROID_RECEPTOR | NEUROENDO | — | Thyroid axis | THYROID_AXIS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Antimicrobial peptidesANTIMICROBIAL_PEPTIDES | IMM | Gut barrier and microbiome | Gut–immune axis | GUT_BARRIER | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Bacterial translocationBACTERIAL_TRANSLOCATION | IMM | Gut barrier and microbiome | Gut–immune axis | GUT_TRANSLOCATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| E-selectinE_SELECTIN | IMM | Endothelial and vascular homeostasis | Innate immunity and cytokines | ENDOTHELIAL_ADHESION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Endothelial NF-κBENDOTHELIAL_NFKB | IMM | Endothelial and vascular homeostasis | Innate immunity and cytokines | VASCULAR_INFLAMMATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Endotoxemia / LPSENDOTOXEMIA_LPS | IMM | Gut barrier and microbiome | Gut–immune axis | GUT_TRANSLOCATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Epithelial barrier functionEPITHELIAL_BARRIER_FUNCTION | IMM | Gut barrier and microbiome | Gut–immune axis | GUT_BARRIER | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Gut–immune axisGUT_IMMUNE_AXIS | IMM | Gut barrier and microbiome | — | GUT_IMMUNE_AXIS | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Gut–immune crosstalkGUT_IMMUNE_CROSSTALK | IMM | Gut barrier and microbiome | Gut–immune axis | MUCOSAL_IMMUNITY | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| ICAM-1ICAM1 | IMM | Endothelial and vascular homeostasis | Innate immunity and cytokines | ENDOTHELIAL_ADHESION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Adaptive immunityIMM_ADAPTIVE | IMM | — | — | IMM_ADAPTIVE | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Intestinal cytokine signallingINTESTINAL_CYTOKINE_SIGNALING | IMM | Gut barrier and microbiome | Innate immunity and cytokines | CYTOKINE_INFLAMMATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Intestinal permeabilityINTESTINAL_PERMEABILITY | IMM | Gut barrier and microbiome | Gut–immune axis | GUT_BARRIER | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Intestinal tight-junction integrityINTESTINAL_TIGHT_JUNCTION_INTEGRITY | IMM | Gut barrier and microbiome | Gut–immune axis | GUT_BARRIER | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Leukocyte adhesionLEUKOCYTE_ADHESION | IMM | Endothelial and vascular homeostasis | Innate immunity and cytokines | ENDOTHELIAL_ADHESION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Leukocyte transmigrationLEUKOCYTE_TRANSMIGRATION | IMM | Endothelial and vascular homeostasis | Innate immunity and cytokines | ENDOTHELIAL_ADHESION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Mucosal immunityMUCOSAL_IMMUNITY | IMM | Gut barrier and microbiome | Gut–immune axis | MUCOSAL_IMMUNITY | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Mucus barrierMUCUS_BARRIER | IMM | Gut barrier and microbiome | Gut–immune axis | GUT_BARRIER | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Vascular inflammationVASCULAR_INFLAMMATION | IMM | Endothelial and vascular homeostasis | Innate immunity and cytokines | VASCULAR_INFLAMMATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| VCAM-1VCAM1 | IMM | Endothelial and vascular homeostasis | Innate immunity and cytokines | ENDOTHELIAL_ADHESION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Innate immunity and cytokinesIMM_INNATE | IMM | — | — | IMM_INNATE | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Antibody responseANTIBODY_RESPONSE | IMM | — | Adaptive immunity | ANTIBODY_RESPONSE | scorable | 1 | 0 | 0 | 0 | 0 | No claims yet |
| Vaccine responseVACCINE_RESPONSE | IMM | — | Adaptive immunity | ANTIBODY_RESPONSE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| B-cell functionB_CELL_FUNCTION | IMM | — | Adaptive immunity | ANTIBODY_RESPONSE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| T-cell functionT_CELL_FUNCTION | IMM | — | Adaptive immunity | T_CELL | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Treg / Th17 balanceTREG_TH17_BALANCE | IMM | — | Adaptive immunity | T_CELL | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| NK-cell functionNK_CELL_FUNCTION | IMM | — | Innate immunity and cytokines | INNATE_CELLS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Macrophage polarizationMACROPHAGE_POLARIZATION | IMM | — | Innate immunity and cytokines | INNATE_CELLS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Cytokine signallingCYTOKINE_SIGNALING | IMM | — | Innate immunity and cytokines | CYTOKINE_INFLAMMATION | scorable | 1 | 0 | 0 | 0 | 0 | No claims yet |
| TNF-alphaTNF_ALPHA | IMM | — | Innate immunity and cytokines | CYTOKINE_INFLAMMATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| IL-6IL6 | IMM | — | Innate immunity and cytokines | CYTOKINE_INFLAMMATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| NF-κBNFKB | IMM | — | Innate immunity and cytokines | CYTOKINE_INFLAMMATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| InflammasomeINFLAMMASOME | IMM | — | Innate immunity and cytokines | CYTOKINE_INFLAMMATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| AutoimmunityAUTOIMMUNITY | IMM | — | Adaptive immunity | AUTOIMMUNITY | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Immune suppressionIMMUNE_SUPPRESSION | IMM | — | Adaptive immunity | IMMUNE_SUPPRESSION | scorable | 1 | 0 | 0 | 0 | 0 | No claims yet |
| Immune activationIMMUNE_ACTIVATION | IMM | — | Innate immunity and cytokines | CYTOKINE_INFLAMMATION | scorable | 1 | 0 | 0 | 0 | 0 | No claims yet |
| Developmental immunotoxicityDEVELOPMENTAL_IMMUNOTOXICITY | IMM | — | Adaptive immunity | DEVELOPMENTAL_IMMUNOTOXICITY | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Acetate metabolismACETATE_METABOLISM | MET | Gut barrier and microbiome | Gut metabolic axis | SCFA_METABOLISM | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Butyrate metabolismBUTYRATE_METABOLISM | MET | Gut barrier and microbiome | Gut metabolic axis | SCFA_METABOLISM | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| DysbiosisDYSBIOSIS | MET | Gut barrier and microbiome | Gut metabolic axis | MICROBIAL_ECOLOGY | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Enteroendocrine signallingENTEROENDOCRINE_SIGNALING | MET | Gut barrier and microbiome | Gut metabolic axis | ENTEROENDOCRINE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| FXR signallingFXR_SIGNALING | MET | Gut barrier and microbiome | Gut metabolic axis | BILE_ACID_SIGNALING | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Ghrelin signallingGHRELIN_SIGNALING | MET | Gut barrier and microbiome | Gut metabolic axis | ENTEROENDOCRINE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| GIP signallingGIP_SIGNALING | MET | Gut barrier and microbiome | Gut metabolic axis | ENTEROENDOCRINE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| GLP-1 signallingGLP1_SIGNALING | MET | Gut barrier and microbiome | Gut metabolic axis | ENTEROENDOCRINE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Gut metabolic axisGUT_METABOLIC_AXIS | MET | Gut barrier and microbiome | — | GUT_METABOLIC_AXIS | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Intestinal nutrient absorptionINTESTINAL_NUTRIENT_ABSORPTION | MET | Gut barrier and microbiome | Gut metabolic axis | INTESTINAL_ABSORPTION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Insulin signalling pathwayMET_INSULIN_SIGNALING | MET | — | — | MET_INSULIN_SIGNALING | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Microbial composition shiftMICROBIAL_COMPOSITION_SHIFT | MET | Gut barrier and microbiome | Gut metabolic axis | MICROBIAL_ECOLOGY | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Microbial functional capacityMICROBIAL_FUNCTIONAL_CAPACITY | MET | Gut barrier and microbiome | Gut metabolic axis | MICROBIAL_FUNCTION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Microbial neuroactive metabolitesMICROBIAL_NEUROACTIVE_METABOLITES | MET | Gut barrier and microbiome | Gut metabolic axis | MICROBIAL_NEUROACTIVE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Microbiome alpha diversityMICROBIOME_ALPHA_DIVERSITY | MET | Gut barrier and microbiome | Gut metabolic axis | MICROBIAL_ECOLOGY | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Microbiome beta diversityMICROBIOME_BETA_DIVERSITY | MET | Gut barrier and microbiome | Gut metabolic axis | MICROBIAL_ECOLOGY | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Propionate metabolismPROPIONATE_METABOLISM | MET | Gut barrier and microbiome | Gut metabolic axis | SCFA_METABOLISM | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| SCFA productionSCFA_PRODUCTION | MET | Gut barrier and microbiome | Gut metabolic axis | SCFA_METABOLISM | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Secondary bile acidsSECONDARY_BILE_ACIDS | MET | Gut barrier and microbiome | Gut metabolic axis | BILE_ACID_SIGNALING | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| TGR5 signallingTGR5_SIGNALING | MET | Gut barrier and microbiome | Gut metabolic axis | BILE_ACID_SIGNALING | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| TMA / TMAO pathwayTMA_TMAO_PATHWAY | MET | Gut barrier and microbiome | Gut metabolic axis | TMA_TMAO | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Tryptophan and indole metabolismTRYPTOPHAN_INDOLE_METABOLISM | MET | Gut barrier and microbiome | Gut metabolic axis | TRYPTOPHAN_INDOLE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Lipid handlingMET_LIPID | MET | — | — | MET_LIPID | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Insulin secretionINSULIN_SECRETION | MET | — | Insulin signalling pathway | INSULIN_SECRETION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Beta-cell functionBETA_CELL_FUNCTION | MET | — | Insulin signalling pathway | INSULIN_SECRETION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Fasting insulinFASTING_INSULIN | MET | — | Insulin signalling pathway | INSULIN_SECRETION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| HyperinsulinemiaHYPERINSULINEMIA | MET | — | Insulin signalling pathway | INSULIN_SECRETION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Insulin resistanceINSULIN_RESISTANCE | MET | — | Insulin signalling pathway | INSULIN_SIGNALING | scorable | 8 | 0 | 0 | 0 | 0 | No claims yet |
| Insulin receptorINSULIN_RECEPTOR | MET | — | Insulin signalling pathway | INSULIN_SIGNALING | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| IRS1IRS1 | MET | — | Insulin signalling pathway | INSULIN_SIGNALING | scorable | 2 | 0 | 0 | 0 | 0 | No claims yet |
| IRS2IRS2 | MET | — | Insulin signalling pathway | INSULIN_SIGNALING | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| PI3KPI3K | MET | — | Insulin signalling pathway | INSULIN_SIGNALING | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| AKTAKT | MET | — | Insulin signalling pathway | INSULIN_SIGNALING | scorable | 1 | 0 | 0 | 0 | 0 | No claims yet |
| GLUT4GLUT4 | MET | — | Insulin signalling pathway | INSULIN_SIGNALING | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| GLUT2GLUT2 | MET | — | Insulin signalling pathway | SUBSTRATE_OXIDATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Hepatic glucose productionHEPATIC_GLUCOSE_PRODUCTION | MET | — | Insulin signalling pathway | HEPATIC_GLUCOSE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| FOXO1FOXO1 | MET | — | Insulin signalling pathway | HEPATIC_GLUCOSE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| PEPCKPEPCK | MET | — | Insulin signalling pathway | HEPATIC_GLUCOSE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Glucose-6-phosphataseG6PASE | MET | — | Insulin signalling pathway | HEPATIC_GLUCOSE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Glycogen metabolismGLYCOGEN_METABOLISM | MET | — | Insulin signalling pathway | HEPATIC_GLUCOSE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| GlycolysisGLYCOLYSIS | MET | — | Insulin signalling pathway | SUBSTRATE_OXIDATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| TCA cycleTCA_CYCLE | MET | — | Insulin signalling pathway | SUBSTRATE_OXIDATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| LipolysisLIPOLYSIS | MET | — | Lipid handling | SUBSTRATE_OXIDATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| LipogenesisLIPOGENESIS | MET | — | Lipid handling | NUCLEAR_RECEPTOR_LIPID | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| SREBPSREBP | MET | — | Lipid handling | NUCLEAR_RECEPTOR_LIPID | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| PPAR-alphaPPAR_ALPHA | MET | — | Lipid handling | NUCLEAR_RECEPTOR_LIPID | scorable | 1 | 0 | 0 | 0 | 0 | No claims yet |
| PPAR-gammaPPAR_GAMMA | MET | — | Lipid handling | NUCLEAR_RECEPTOR_LIPID | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| RXRRXR | MET | — | Lipid handling | NUCLEAR_RECEPTOR_LIPID | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| AdipogenesisADIPOGENESIS | MET | — | Lipid handling | NUCLEAR_RECEPTOR_LIPID | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Adipocyte differentiationADIPOCYTE_DIFFERENTIATION | MET | — | Lipid handling | NUCLEAR_RECEPTOR_LIPID | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| LeptinLEPTIN | MET | — | Lipid handling | ADIPOKINES | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| AdiponectinADIPONECTIN | MET | — | Lipid handling | ADIPOKINES | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Fatty acid oxidationFATTY_ACID_OXIDATION | MET | — | Lipid handling | SUBSTRATE_OXIDATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| DiacylglycerolDAG | MET | — | Lipid handling | ECTOPIC_LIPID | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| CeramideCERAMIDE | MET | — | Lipid handling | ECTOPIC_LIPID | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Ectopic lipidECTOPIC_LIPID | MET | — | Lipid handling | ECTOPIC_LIPID | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Hepatic steatosisHEPATIC_STEATOSIS | MET | — | Lipid handling | ECTOPIC_LIPID | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Glucose toleranceGLUCOSE_TOLERANCE | MET | — | Insulin signalling pathway | GLUCOSE_TOLERANCE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Electron transport complexesMIT_ETC | MITO | — | — | MIT_ETC | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Bioenergetic outputMIT_OUTPUT | MITO | — | — | MIT_OUTPUT | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Mitochondrial dynamicsMIT_DYNAMICS | MITO | — | — | MIT_DYNAMICS | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| ETC complex IETC_COMPLEX_I | MITO | — | Electron transport complexes | ETC_COMPLEX_I | scorable | 2 | 0 | 0 | 0 | 0 | No claims yet |
| ETC complex IIETC_COMPLEX_II | MITO | — | Electron transport complexes | ETC_COMPLEX_II | scorable | 4 | 0 | 0 | 0 | 0 | No claims yet |
| ETC complex IIIETC_COMPLEX_III | MITO | — | Electron transport complexes | ETC_COMPLEX_III | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| ETC complex IVETC_COMPLEX_IV | MITO | — | Electron transport complexes | ETC_COMPLEX_IV | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| ATP synthaseATP_SYNTHASE | MITO | — | Electron transport complexes | ATP_SYNTHASE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| ETC fluxETC_FLUX | MITO | — | Bioenergetic output | BIOENERGETIC_OUTPUT | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Electron transfer rateELECTRON_TRANSFER_RATE | MITO | — | Bioenergetic output | BIOENERGETIC_OUTPUT | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Electron leakELECTRON_LEAK | MITO | — | Bioenergetic output | ELECTRON_LEAK | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Electron-transfer couplingELECTRON_TRANSFER_COUPLING | MITO | — | Bioenergetic output | BIOENERGETIC_OUTPUT | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Reorganization energyREORGANIZATION_ENERGY | MITO | — | Bioenergetic output | REORGANIZATION_ENERGY | research only | 1 | 0 | 0 | 0 | 0 | No claims yet |
| Membrane potentialMEMBRANE_POTENTIAL | MITO | — | Bioenergetic output | BIOENERGETIC_OUTPUT | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Proton gradientPROTON_GRADIENT | MITO | — | Bioenergetic output | BIOENERGETIC_OUTPUT | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Proton leakPROTON_LEAK | MITO | — | Bioenergetic output | BIOENERGETIC_OUTPUT | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Coupling efficiencyCOUPLING_EFFICIENCY | MITO | — | Bioenergetic output | BIOENERGETIC_OUTPUT | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Oxygen consumptionOXYGEN_CONSUMPTION | MITO | — | Bioenergetic output | BIOENERGETIC_OUTPUT | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| ATP productionATP_PRODUCTION | MITO | — | Bioenergetic output | BIOENERGETIC_OUTPUT | scorable | 8 | 0 | 0 | 0 | 0 | No claims yet |
| CO2 productionCO2_PRODUCTION | MITO | — | Bioenergetic output | BIOENERGETIC_OUTPUT | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| NADH/NAD ratioNADH_NAD_RATIO | MITO | — | Bioenergetic output | REDOX_COFACTORS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| FADH2 metabolismFADH2_METABOLISM | MITO | — | Bioenergetic output | REDOX_COFACTORS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| SuccinateSUCCINATE | MITO | — | Electron transport complexes | ETC_COMPLEX_II | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| FumarateFUMARATE | MITO | — | Electron transport complexes | ETC_COMPLEX_II | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Mitochondrial beta-oxidationBETA_OXIDATION | MITO | — | Bioenergetic output | BETA_OXIDATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Mitochondrial biogenesisMITOCHONDRIAL_BIOGENESIS | MITO | — | Mitochondrial dynamics | MITOCHONDRIAL_DYNAMICS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| PGC-1αPGC1_ALPHA | MITO | — | Mitochondrial dynamics | MITOCHONDRIAL_DYNAMICS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Mitochondrial fissionMITOCHONDRIAL_FISSION | MITO | — | Mitochondrial dynamics | MITOCHONDRIAL_DYNAMICS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Mitochondrial fusionMITOCHONDRIAL_FUSION | MITO | — | Mitochondrial dynamics | MITOCHONDRIAL_DYNAMICS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| MitophagyMITOPHAGY | MITO | — | Mitochondrial dynamics | MITOCHONDRIAL_DYNAMICS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Mitochondrial transportMITOCHONDRIAL_TRANSPORT | MITO | — | Mitochondrial dynamics | MITOCHONDRIAL_DYNAMICS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Mitochondrial calciumMITOCHONDRIAL_CALCIUM | MITO | — | Mitochondrial dynamics | MITOCHONDRIAL_DYNAMICS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Endothelial ROSENDOTHELIAL_ROS | REDOX | Endothelial and vascular homeostasis | Reactive species | ENDOTHELIAL_ROS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Reactive speciesRED_ROS | REDOX | — | — | RED_ROS | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Antioxidant systemsRED_ANTIOXIDANT | REDOX | — | — | RED_ANTIOXIDANT | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Oxidative damageRED_DAMAGE | REDOX | — | — | RED_DAMAGE | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| SuperoxideSUPEROXIDE | REDOX | — | Reactive species | ROS_GENERATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Hydrogen peroxideHYDROGEN_PEROXIDE | REDOX | — | Reactive species | ROS_GENERATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Hydroxyl radicalHYDROXYL_RADICAL | REDOX | — | Reactive species | ROS_GENERATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| ROS (total)ROS_TOTAL | REDOX | — | Reactive species | ROS_GENERATION | scorable | 10 | 0 | 0 | 0 | 0 | No claims yet |
| Reactive nitrogen speciesRNS | REDOX | — | Reactive species | RNS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Nitric oxideNITRIC_OXIDE | REDOX | — | Reactive species | RNS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Redox signallingREDOX_SIGNALING | REDOX | — | Reactive species | REDOX_SIGNALING | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| MitohormesisMITOHORMESIS | REDOX | — | Reactive species | REDOX_SIGNALING | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| GlutathioneGLUTATHIONE | REDOX | — | Antioxidant systems | ANTIOXIDANT_SYSTEM | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| GSH/GSSGGSH_GSSG | REDOX | — | Antioxidant systems | ANTIOXIDANT_SYSTEM | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Superoxide dismutaseSOD | REDOX | — | Antioxidant systems | ANTIOXIDANT_SYSTEM | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| CatalaseCATALASE | REDOX | — | Antioxidant systems | ANTIOXIDANT_SYSTEM | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Glutathione peroxidaseGLUTATHIONE_PEROXIDASE | REDOX | — | Antioxidant systems | ANTIOXIDANT_SYSTEM | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| NRF2NRF2 | REDOX | — | Antioxidant systems | ANTIOXIDANT_SYSTEM | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| KEAP1KEAP1 | REDOX | — | Antioxidant systems | ANTIOXIDANT_SYSTEM | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| SirtuinsSIRTUIN | REDOX | — | Antioxidant systems | SIRTUIN | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Lipid peroxidationLIPID_PEROXIDATION | REDOX | — | Oxidative damage | OXIDATIVE_DAMAGE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Protein oxidationPROTEIN_OXIDATION | REDOX | — | Oxidative damage | OXIDATIVE_DAMAGE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| DNA oxidationDNA_OXIDATION | REDOX | — | Oxidative damage | OXIDATIVE_DAMAGE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| 8-OHdG8_OHDG | REDOX | — | Oxidative damage | OXIDATIVE_DAMAGE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Dopamine quinoneDOPAMINE_QUINONE | REDOX | — | Oxidative damage | REACTIVE_METABOLITES | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Reactive metabolitesREACTIVE_METABOLITES | REDOX | — | Oxidative damage | REACTIVE_METABOLITES | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| ER stressER_STRESS | REDOX | — | Oxidative damage | ER_STRESS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Unfolded protein responseUNFOLDED_PROTEIN_RESPONSE | REDOX | — | Oxidative damage | ER_STRESS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| JNKJNK | REDOX | — | Oxidative damage | STRESS_KINASE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| IKKβIKKB | REDOX | — | Oxidative damage | STRESS_KINASE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| ApoptosisAPOPTOSIS | REDOX | — | Oxidative damage | CELL_DEATH | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| FerroptosisFERROPTOSIS | REDOX | — | Oxidative damage | CELL_DEATH | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| AutophagyAUTOPHAGY | REDOX | — | Oxidative damage | CELL_DEATH | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Oxidative damageOXIDATIVE_DAMAGE | REDOX | — | Oxidative damage | OXIDATIVE_DAMAGE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Enterohepatic recirculationENTEROHEPATIC_RECIRCULATION | EXPOSURE · not in profile | Host–microbe xenobiotic interaction | Host–microbe xenobiotic axis | ENTEROHEPATIC_RECIRCULATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Exposure contextEXP_CONTEXT | EXPOSURE · not in profile | — | — | EXP_CONTEXT | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Host–microbe xenobiotic axisHOST_MICROBE_AXIS | EXPOSURE · not in profile | Host–microbe xenobiotic interaction | — | HOST_MICROBE_AXIS | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Microbial bioactivationMICROBIAL_BIOACTIVATION | EXPOSURE · not in profile | Host–microbe xenobiotic interaction | Host–microbe xenobiotic axis | MICROBIAL_XENOBIOTIC_TRANSFORMATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Microbial deconjugationMICROBIAL_DECONJUGATION | EXPOSURE · not in profile | Host–microbe xenobiotic interaction | Host–microbe xenobiotic axis | MICROBIAL_XENOBIOTIC_TRANSFORMATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Microbial detoxificationMICROBIAL_DETOXIFICATION | EXPOSURE · not in profile | Host–microbe xenobiotic interaction | Host–microbe xenobiotic axis | MICROBIAL_XENOBIOTIC_TRANSFORMATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Microbiome-modified bioavailabilityMICROBIOME_MODIFIED_BIOAVAILABILITY | EXPOSURE · not in profile | Host–microbe xenobiotic interaction | Host–microbe xenobiotic axis | MICROBIOME_MODIFIED_BIOAVAILABILITY | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Microbiome-modified drug responseMICROBIOME_MODIFIED_DRUG_RESPONSE | EXPOSURE · not in profile | Host–microbe xenobiotic interaction | Host–microbe xenobiotic axis | MICROBIOME_MODIFIED_DRUG_RESPONSE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Microbiome xenobiotic metabolismMICROBIOME_XENOBIOTIC_METABOLISM | EXPOSURE · not in profile | Host–microbe xenobiotic interaction | Host–microbe xenobiotic axis | MICROBIAL_XENOBIOTIC_TRANSFORMATION | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Xenobiotic-induced microbiome changeXENOBIOTIC_INDUCED_MICROBIOME_CHANGE | EXPOSURE · not in profile | Host–microbe xenobiotic interaction | Host–microbe xenobiotic axis | XENOBIOTIC_INDUCED_MICROBIOME_CHANGE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Developmental windowDEVELOPMENTAL_WINDOW_CONTEXT | EXPOSURE · not in profile | — | Exposure context | EXPOSURE_CONTEXT | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Co-formulant contextCO_FORMULANT_CONTEXT | EXPOSURE · not in profile | — | Exposure context | EXPOSURE_CONTEXT | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Mixture contextMIXTURE_CONTEXT | EXPOSURE · not in profile | — | Exposure context | EXPOSURE_CONTEXT | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Therapeutic versus environmental doseTHERAPEUTIC_VERSUS_ENVIRONMENTAL | EXPOSURE · not in profile | — | Exposure context | EXPOSURE_CONTEXT | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| AngiogenesisANGIOGENESIS | VASCULAR · not in profile | Endothelial and vascular homeostasis | Vascular axis | ANGIOGENESIS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| CoagulationCOAGULATION | VASCULAR · not in profile | Endothelial and vascular homeostasis | Vascular axis | HAEMOSTASIS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Endothelial nitric oxide bioavailabilityENDOTHELIAL_NO_BIOAVAILABILITY | VASCULAR · not in profile | Endothelial and vascular homeostasis | Vascular axis | VASCULAR_TONE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Endothelial permeabilityENDOTHELIAL_PERMEABILITY | VASCULAR · not in profile | Endothelial and vascular homeostasis | Vascular axis | ENDOTHELIAL_BARRIER | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Endothelial proliferationENDOTHELIAL_PROLIFERATION | VASCULAR · not in profile | Endothelial and vascular homeostasis | Vascular axis | ANGIOGENESIS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Endothelial senescenceENDOTHELIAL_SENESCENCE | VASCULAR · not in profile | Endothelial and vascular homeostasis | Vascular axis | ENDOTHELIAL_SENESCENCE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Endothelial tight-junction integrityENDOTHELIAL_TIGHT_JUNCTION_INTEGRITY | VASCULAR · not in profile | Endothelial and vascular homeostasis | Vascular axis | ENDOTHELIAL_BARRIER | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| eNOS signallingENOS_SIGNALING | VASCULAR · not in profile | Endothelial and vascular homeostasis | Vascular axis | VASCULAR_TONE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| FibrinolysisFIBRINOLYSIS | VASCULAR · not in profile | Endothelial and vascular homeostasis | Vascular axis | HAEMOSTASIS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Microvascular barrier functionMICROVASCULAR_BARRIER_FUNCTION | VASCULAR · not in profile | Endothelial and vascular homeostasis | Vascular axis | ENDOTHELIAL_BARRIER | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Microvascular functionMICROVASCULAR_FUNCTION | VASCULAR · not in profile | Endothelial and vascular homeostasis | Vascular axis | ANGIOGENESIS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Platelet activationPLATELET_ACTIVATION | VASCULAR · not in profile | Endothelial and vascular homeostasis | Vascular axis | HAEMOSTASIS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Thrombosis mechanismTHROMBOSIS | VASCULAR · not in profile | Endothelial and vascular homeostasis | Vascular axis | HAEMOSTASIS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Vascular axisVASCULAR_AXIS | VASCULAR · not in profile | Endothelial and vascular homeostasis | — | VASCULAR_AXIS | grouping only | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Vascular remodellingVASCULAR_REMODELING | VASCULAR · not in profile | Endothelial and vascular homeostasis | Vascular axis | ANGIOGENESIS | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| Vascular toneVASCULAR_TONE | VASCULAR · not in profile | Endothelial and vascular homeostasis | Vascular axis | VASCULAR_TONE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| VasoconstrictionVASOCONSTRICTION | VASCULAR · not in profile | Endothelial and vascular homeostasis | Vascular axis | VASCULAR_TONE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |
| VasodilationVASODILATION | VASCULAR · not in profile | Endothelial and vascular homeostasis | Vascular axis | VASCULAR_TONE | scorable | 0 | 0 | 0 | 0 | 0 | No claims yet |