EDCtox

Mechanistic evidence atlas. Scores summarise biological direction and magnitude. They are not a toxicity rank or a human-risk number.

Compounds

Melatonin

Melatonin

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Category
hormone · Endogenous hormone / pharmaceutical
Record
specific compound · in current use
Identifiers
CAS 73-31-4 · C13H16N2O2
Aliases
5-methoxy-N-acetyltryptamine, N-acetyl-5-methoxytryptamine

Endogenous pineal hormone and a pharmaceutical used for sleep. High MT1/MT2 activity is physiological. Developmental reproductive effects of long-term childhood use are not established in this seed.

Flags: pharmaceutical · endogenous

Phase-1 numbers are seed hypotheses. They are not curated consensus, not a toxicity total, and not a statement of human risk. Association is not written as causation.

HIGH · developmental relevance uncertain · DEV

Long-term childhood melatonin use and puberty timing are insufficiently demonstrated.

Suggested research: Prospective paediatric studies with pubertal endpoints, dose, and duration.

MODERATE · insufficient human evidence · REDOX

Developmental redox signalling of melatonin is not distinguished from adult experimental protection.

Suggested research: Developmental models that separate physiological circadian signalling from toxicant co-exposure.