protects against Paraquat
Experimental reports of reduced oxidative and mitochondrial neuronal injury. Not a demonstrated clinical antidote.
Melatonin
Melatonin
- Category
- hormone · Endogenous hormone / pharmaceutical
- Record
- specific compound · in current use
- Identifiers
- CAS 73-31-4 · C13H16N2O2
- Aliases
- 5-methoxy-N-acetyltryptamine, N-acetyl-5-methoxytryptamine
Endogenous pineal hormone and a pharmaceutical used for sleep. High MT1/MT2 activity is physiological. Developmental reproductive effects of long-term childhood use are not established in this seed.
Flags: pharmaceutical · endogenous
Phase-1 numbers are seed hypotheses. They are not curated consensus, not a toxicity total, and not a statement of human risk. Association is not written as causation.
protects against Paraquat · -3
Experimental models report less oxidative and mitochondrial neuronal injury when melatonin is present with paraquat. This is not demonstrated clinical benefit.
Animal and cellular protection does not establish a treatment effect in humans. Dose, timing, and formulation are not curated.
LOW confidence · H1. Experimental protection is not clinical benefit. · Brain · Dopaminergic neuron · Experimental models under toxicant or oxidative stress