EDCtox

Mechanistic evidence atlas. Scores summarise biological direction and magnitude. They are not a toxicity rank or a human-risk number.

Compounds

Melatonin

Melatonin

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Category
hormone · Endogenous hormone / pharmaceutical
Record
specific compound · in current use
Identifiers
CAS 73-31-4 · C13H16N2O2
Aliases
5-methoxy-N-acetyltryptamine, N-acetyl-5-methoxytryptamine

Endogenous pineal hormone and a pharmaceutical used for sleep. High MT1/MT2 activity is physiological. Developmental reproductive effects of long-term childhood use are not established in this seed.

Flags: pharmaceutical · endogenous

Phase-1 numbers are seed hypotheses. They are not curated consensus, not a toxicity total, and not a statement of human risk. Association is not written as causation.

REP · Reproductive endocrinology

Fertility

FERTILITY · group GONADAL_FUNCTION · Gonadal function · scorable

Fertility. Mechanism node for evidence linkage. A row here is not itself a finding.

Score +1Direction uncertainVery low confidenceH0seed hypothesisreview v1

Reproductive concern is seeded at +1 and is uncertain. It is not evidence of developmental toxicity, and it is not the MT1/MT2 physiological activity.

Fertility node. Puberty timing is recorded separately on the developmental domain.

Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

  • Insufficient human evidence
  • Developmental relevance uncertain

No evidence finding is linked yet.

Score history
  • 2026-10-03: — → +1. Initial seed hypothesis, version 1. Not a curated consensus.

DEV · Developmental endocrinology

Puberty timing

PUBERTY_TIMING · group PUBERTY · Puberty and growth · scorable

Puberty timing. Mechanism node for evidence linkage. A row here is not itself a finding.

Score +1Direction uncertainVery low confidenceH0seed hypothesisreview v1

Developmental seed at +1. Long-term childhood puberty effects are not demonstrated.

Kept separate from protective mitochondrial and redox experiments.

Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

  • Insufficient human evidence
  • Developmental relevance uncertain

No evidence finding is linked yet.

Score history
  • 2026-10-03: — → +1. Initial seed hypothesis, version 1. Not a curated consensus.

NEUROENDO · Neuroendocrine, HPA, and circadian

Melatonin MT1

MELATONIN_MT1 · group MELATONIN_RECEPTOR · Melatonin receptors · scorable

MT1 receptor signalling. High activity of the endogenous ligand is physiological and is not a toxicity score.

Score not quantifiedPhysiological activityHigh confidenceH4seed hypothesisreview v1

Endogenous ligand activity at MT1 is high and physiological. No signed disruption score is assigned.

Same receptor cluster as MT2, so the two receptors are not two toxicity points.

Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

    No evidence finding is linked yet.

    Score history
    • 2026-10-03: — → —. Initial seed hypothesis, version 1. Not a curated consensus.

    Melatonin MT2

    MELATONIN_MT2 · group MELATONIN_RECEPTOR · Melatonin receptors · scorable

    MT2 receptor signalling. High activity of the endogenous ligand is physiological and is not a toxicity score.

    Score not quantifiedPhysiological activityHigh confidenceH4seed hypothesisreview v1

    Endogenous ligand activity at MT2 is high and physiological.

    Capped in the melatonin-receptor cluster with MT1.

    Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → —. Initial seed hypothesis, version 1. Not a curated consensus.

      IMM · Immunology and immunoendocrinology

      Immune suppression

      IMMUNE_SUPPRESSION · group IMMUNE_SUPPRESSION · Adaptive immunity · scorable

      Immune suppression. Mechanism node for evidence linkage. A row here is not itself a finding.

      Score -2Protective or restorative signalLow confidenceH1seed hypothesisreview v1

      Experimental immunomodulation seeded at −2, the lower-magnitude end of −2 to −3. Not a clinical anti-inflammatory indication.

      Immune-suppression cluster. Direction is protective in the experimental seed, which is not the same as therapeutic efficacy.

      Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      • Insufficient human evidence

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → -2. Initial seed hypothesis, version 1. Not a curated consensus.

      MET · Systemic metabolism

      Insulin resistance

      INSULIN_RESISTANCE · group INSULIN_SIGNALING · Insulin signalling pathway · scorable

      Impaired insulin action at target tissues. A mechanistic insulin-signalling change is not automatically a diagnosis of diabetes.

      Score not quantifiedContext-dependentVery low confidenceH1seed hypothesisreview v1

      Metabolic endpoints were discussed around −1 to +1. The range crosses zero, so no signed score is stored.

      Context-dependent. A single integer would invent a direction.

      Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      • Conflicting evidence

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → —. Initial seed hypothesis, version 1. Not a curated consensus.

      MITO · Mitochondrial bioenergetics

      ATP production

      ATP_PRODUCTION · group BIOENERGETIC_OUTPUT · Bioenergetic output · scorable

      ATP production. Mechanism node for evidence linkage. A row here is not itself a finding.

      Score -3Protective or restorative signalLow confidenceH1seed hypothesisreview v1

      Exposure: experimental · adult · Experimental models under toxicant or oxidative stress

      Biological context: Mitochondrion

      Protective mitochondrial seed at −3 under toxicant or oxidative stress, the lower-magnitude end of −3 to −4. Not a claim of clinical benefit.

      Experimental co-exposure context. Not the endogenous physiology row.

      Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      • Insufficient human evidence
      • Dose relevance uncertain

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → -3. Initial seed hypothesis, version 1. Not a curated consensus.

      REDOX · Redox and cellular stress

      ROS (total)

      ROS_TOTAL · group ROS_GENERATION · Reactive species · scorable

      ROS (total). Mechanism node for evidence linkage. A row here is not itself a finding.

      Score -4Protective or restorative signalLow confidenceH1seed hypothesisreview v1

      Exposure: experimental · adult · Experimental models under toxicant or oxidative stress

      Biological context: Brain · Dopaminergic neuron

      Protective redox seed at −4 under oxidative injury in experimental models. Experimental protection is not demonstrated clinical benefit.

      ROS cluster in the toxicant-stress context.

      Phase-1 seed hypothesis, not a curated systematic review. Where a range was discussed, the stored integer is the conservative end closer to zero. A score is biological direction and magnitude, not human risk.

      • Insufficient human evidence
      • Dose relevance uncertain

      No evidence finding is linked yet.

      Score history
      • 2026-10-03: — → -4. Initial seed hypothesis, version 1. Not a curated consensus.